FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090041105> ?p ?o ?g. }

• W2090041105 endingPage "169" @default.
• W2090041105 startingPage "158" @default.
• W2090041105 abstract "The acute porphyrias are a group of disorders which result from inherited defects in the enzymes of the heme biosynthetic pathway. Affected patients are prone to potentially fatal acute attacks. These attacks are frequently precipitated by exposure to commonly used drugs. Correctly identifying the safety or otherwise of drugs in porphyria is therefore important. In this review we describe how clinical experience and the findings of experimental systems using whole animal or cell culture models have been interpreted to determine porphyrogenicity, that is the potential of a drug to induce an acute attack in a patient carrying a gene for acute porphyria. It is now well established that induction of delta-aminolevulinic acid synthase, the rate controlling enzyme of the heme biosynthetic pathway, is fundamental to porphyrogenicity, and that drug-induced hepatic heme depletion via induction or suicidal inactivation of cytochrome P450 is central to this process. The process is now sufficiently well understood that prediction of porphyrogenicity from structural and functional information alone would appear to be justified." @default.
• W2090041105 created "2016-06-24" @default.
• W2090041105 creator A5002069487 @default.
• W2090041105 creator A5074842789 @default.
• W2090041105 creator A5090045860 @default.
• W2090041105 date "2011-11-01" @default.
• W2090041105 modified "2023-10-07" @default.
• W2090041105 title "Drugs in porphyria: From observation to a modern algorithm-based system for the prediction of porphyrogenicity" @default.
• W2090041105 cites W1496019889 @default.
• W2090041105 cites W1501715468 @default.
• W2090041105 cites W1558705752 @default.
• W2090041105 cites W1558998350 @default.
• W2090041105 cites W1560770924 @default.
• W2090041105 cites W1604536885 @default.
• W2090041105 cites W1668937986 @default.
• W2090041105 cites W171032861 @default.
• W2090041105 cites W178514093 @default.
• W2090041105 cites W1900912696 @default.
• W2090041105 cites W1903214678 @default.
• W2090041105 cites W1943047487 @default.
• W2090041105 cites W1963890030 @default.
• W2090041105 cites W1965805948 @default.
• W2090041105 cites W1968235034 @default.
• W2090041105 cites W1968722752 @default.
• W2090041105 cites W1969668216 @default.
• W2090041105 cites W1972646235 @default.
• W2090041105 cites W1974504902 @default.
• W2090041105 cites W1983008507 @default.
• W2090041105 cites W1983375352 @default.
• W2090041105 cites W1988715568 @default.
• W2090041105 cites W1989689177 @default.
• W2090041105 cites W1991693971 @default.
• W2090041105 cites W1996409582 @default.
• W2090041105 cites W1998811544 @default.
• W2090041105 cites W2001381178 @default.
• W2090041105 cites W2009124285 @default.
• W2090041105 cites W2015185599 @default.
• W2090041105 cites W2015661757 @default.
• W2090041105 cites W2021343367 @default.
• W2090041105 cites W2021960255 @default.
• W2090041105 cites W2022794365 @default.
• W2090041105 cites W2023644648 @default.
• W2090041105 cites W2024005016 @default.
• W2090041105 cites W2028105139 @default.
• W2090041105 cites W2028890879 @default.
• W2090041105 cites W2030918884 @default.
• W2090041105 cites W2034973225 @default.
• W2090041105 cites W2036187950 @default.
• W2090041105 cites W2036370236 @default.
• W2090041105 cites W2039775584 @default.
• W2090041105 cites W2041495545 @default.
• W2090041105 cites W2044369247 @default.
• W2090041105 cites W2056602215 @default.
• W2090041105 cites W2057250534 @default.
• W2090041105 cites W2059924653 @default.
• W2090041105 cites W2065600927 @default.
• W2090041105 cites W2065896521 @default.
• W2090041105 cites W2066590601 @default.
• W2090041105 cites W2070879037 @default.
• W2090041105 cites W2075634723 @default.
• W2090041105 cites W2075944998 @default.
• W2090041105 cites W2077169826 @default.
• W2090041105 cites W2082288678 @default.
• W2090041105 cites W2082453415 @default.
• W2090041105 cites W2084467721 @default.
• W2090041105 cites W2087731685 @default.
• W2090041105 cites W2088473719 @default.
• W2090041105 cites W2089372668 @default.
• W2090041105 cites W2089559104 @default.
• W2090041105 cites W2090545708 @default.
• W2090041105 cites W2091065585 @default.
• W2090041105 cites W2091582819 @default.
• W2090041105 cites W2096589216 @default.
• W2090041105 cites W2110437968 @default.
• W2090041105 cites W2117206446 @default.
• W2090041105 cites W2126859674 @default.
• W2090041105 cites W2130091396 @default.
• W2090041105 cites W2130431353 @default.
• W2090041105 cites W2139251954 @default.
• W2090041105 cites W2139452536 @default.
• W2090041105 cites W2145240986 @default.
• W2090041105 cites W2154324288 @default.
• W2090041105 cites W2158422285 @default.
• W2090041105 cites W2158779847 @default.
• W2090041105 cites W2159495866 @default.
• W2090041105 cites W2287508791 @default.
• W2090041105 cites W2316941052 @default.
• W2090041105 cites W2411653607 @default.
• W2090041105 cites W24318333 @default.
• W2090041105 cites W2463444282 @default.
• W2090041105 cites W4210973172 @default.
• W2090041105 cites W4232351148 @default.
• W2090041105 cites W4245987723 @default.
• W2090041105 cites W4301906560 @default.
• W2090041105 cites W58001459 @default.
• W2090041105 doi "https://doi.org/10.1016/j.pharmthera.2011.06.001" @default.
• W2090041105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21704073" @default.
• W2090041105 hasPublicationYear "2011" @default.

• next