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- W2090046230 abstract "The work of Harington & Randall [1929] provided a convenient chemical method, based on the estimation of acid-insoluble iodine, for the assay of dried thyroid preparations. This method appears to be satisfactory for thyroid preparations, in which all the acid-insoluble iodine is thyroxine iodine. As a result, the biological assay of thyroidal activity has been much neglected and has mainly been used for determining the activity of substances related to thyroxine. In the last few years, artificially iodinated proteins (mostly iodinated casein), which possess high thyroidal activity, have come into use. These iodinated proteins contain a large amount of acid-insoluble iodine, and it is evident that only a small and variable proportion of it represents thyroxine or other substance with similar activity [Deanesly & Parkes, 1945b]. Chemical assay of such preparations is thus of little value, and the whole problem of the biological assay of thyroidal activity has had" @default.
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- W2090046230 date "1946-01-01" @default.
- W2090046230 modified "2023-10-16" @default.
- W2090046230 title "ASSAY OF THYROIDAL ACTIVITY BY A CLOSED VESSEL TECHNIQUE" @default.
- W2090046230 doi "https://doi.org/10.1677/joe.0.0050186" @default.
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