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- W2090068178 abstract "Cell-free hemoglobin, suitably modified to confer a physiological oxygen affinity and prolonged plasma retention, is a candidate for a temporary substitute for red blood cells. Such a solution would probably find wide clinical acceptance because the risks of disease transmission from banked human blood are significant. This chapter discusses the pilot-scale preparation of hemoglobin solutions. The production facility is housed in four separate, but connected, rooms: one contains the system for generation of pyrogen-free water (PFW), the second is used for reagent preparation, the third contains the filtration assemblies and the bioreactor, and the fourth is a 4° cold room that houses the preparative high-performance liquid chromatography (HPLC) equipment. An additional large walk-in cold room is available to store large tanks of buffers. The apparatus used for hemoglobin preparation consists of several components, including a manifold for emptying bags of outdated blood; cross-flow filtration devices for washing, lysis, and purification; a bioreactor for cross-linking hemoglobin; a preparative-scale HPLC apparatus; and a hood for final filling of product into sterile bags." @default.
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- W2090068178 date "2009-06-01" @default.
- W2090068178 modified "2023-10-18" @default.
- W2090068178 title "Abstract: P1393 ANTHOCYANIN SUPPLEMENTATION IMPROVES THE SERUM LDL-C AND HDL-C LEVELS ASSOCIATED WITH CETP INHIBITION IN DYSLIPIDEMIC SUBJECTS" @default.
- W2090068178 doi "https://doi.org/10.1016/s1567-5688(09)71401-1" @default.
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