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• W2090077609 abstract "Transforming growth factor α messenger RNA and protein levels are highest in the striatum, the target area of mesencephalic dopaminergic neurons of the substantia nigra, suggesting a role as a target-derived neurotrophic factor for these cells. To test this hypothesis, we characterized the actions of transforming growth factor α on fetal rat dopaminergic neurons in culture. Transforming growth factor α promoted dopamine uptake in a dose- and time-dependent manner. Administration of transforming growth factor α at the time of plating for 2 h produced a significant increase in dopamine uptake after five days of growth in vitro. As cultures aged they became less responsive to transforming growth factor α, such that longer times of exposure were required to elicit a similar, but weaker, response. Dopaminergic cell survival was selectively promoted by transforming growth factor α, since there was an increase in the number of tyrosine hydroxylase-immunostained cells without a parallel increase in the total number of neuron-specific enolase-immunopositive cells. Neurite length, branch number and soma area of tyrosine hydroxylase-immunopositive cells also were enhanced by transforming growth factor α treatment. Increases in each of the dopaminergic parameters due to transforming growth factor α were accompanied by a rise in glial cell number, making it possible that these effects were mediated by this cell population. The neurotrophin antagonist, K252b, failed to inhibit the transforming growth factor α-induced increase in dopamine uptake, indicating that transforming growth factor α's effects were not mediated by neurotrophin mechanisms. The actions of transforming growth factor α on the differentiation of dopaminergic neurons only partially overlapped with those of epidermal growth factor. Thus, while transforming growth factor α and epidermal growth factor are believed to share the same receptor they differentially affect dopaminergic cell development in vitro. These results indicate that transforming growth factor α is a trophic factor for mesencephalic cells in culture and suggests that transforming growth factor α plays a physiological role in the development of these cells in vivo." @default.
• W2090077609 created "2016-06-24" @default.
• W2090077609 creator A5022567561 @default.
• W2090077609 creator A5054270816 @default.
• W2090077609 date "1993-08-01" @default.
• W2090077609 modified "2023-09-23" @default.
• W2090077609 title "Trophic actions of transforming growth factor α on mesencephalic dopaminergic neurons developing in culture" @default.
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• W2090077609 doi "https://doi.org/10.1016/0306-4522(93)90307-2" @default.
• W2090077609 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7901801" @default.
• W2090077609 hasPublicationYear "1993" @default.
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