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• W2090079013 abstract "Recently it has been shown that lactotropic cells in the anterior pituitary gland produce and secrete transforming growth factor-beta 1-(TGF-beta 1) like peptide. The in vivo action(s) of this peptide growth factor on lactotropic cells have not been studied. In this study we determined the effects of TGF-beta 1 on lactotropic cell function in estradiol-17 beta-treated ovariectomized rats. Intrapituitary administration of TGF-beta 1 significantly inhibited plasma levels of prolactin (PRL). In addition, TGF-beta 1 decreased pituitary weight and the DNA synthesis in lactotropes and reduced the PRL levels in the pituitary. These results suggest that TGF-beta 1 may be a physiological regulator of PRL secretion and lactotropic cell proliferation." @default.
• W2090079013 created "2016-06-24" @default.
• W2090079013 creator A5043693469 @default.
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• W2090079013 date "1997-04-01" @default.
• W2090079013 modified "2023-10-14" @default.
• W2090079013 title "TRANSFORMING GROWTH FACTOR-β1 INHIBITS PROLACTIN SECRETION AND LACTOTROPIC CELL PROLIFERATION IN THE PITUITARY OF OESTROGEN-TREATED FISCHER 344 RATS" @default.
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• W2090079013 doi "https://doi.org/10.1016/s0197-0186(96)00087-3" @default.
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