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- W2090081796 abstract "The synthesis of DNA in L-1210 cells was selectively inhibited by BCNU [1,3-bis-(2-chloroethyl)-1-nitrosourea, NSC 409962]. When the DNA chain growth in exponentially grown L-1210 cells was analyzed by alkaline sucrose gradient centrifugation, the initially synthesized DNA had short segments (approximately 5S) which increased in size to 30, 70 and to over 100S. When treated with BCNU, the short, newly synthesized DNA segments accumulated; the molecular weights were 5-30S. While it appears that BCNU inhibits the early elongation steps of newly synthesized DNA, the chasing experiments suggest that the drug does not affect the joining process from replicon-sized DNA (70S) to bottom peaks with a molecular weight of over 100S." @default.
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- W2090081796 date "1979-01-01" @default.
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- W2090081796 title "Effect of 1,3-bis(2-chloroethyl)-1-nitrosourea on newly synthesized DNA in L-1210 cells" @default.
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- W2090081796 doi "https://doi.org/10.1016/0006-2952(79)90244-2" @default.
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