FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090085755> ?p ?o ?g. }

• W2090085755 endingPage "2180" @default.
• W2090085755 startingPage "2174" @default.
• W2090085755 abstract "Lipid droplets (LDs) are intracellular storage sites of neutral lipids, which accumulate in fatty liver disease. Here, we investigated the effects of fatty acids and glucose on LD formation in a cultured human hepatocyte, HuH7, by adding them to culture media. Fatty acids with carbohydrate chains C12—C18 efficiently induced LDs, but those of C8 and C10 were ineffective. Glucose did not induce LD formation even in the presence of insulin. Oleic acid induced significant increases in cellular neutral lipids, and cell fractionation revealed that most of the newly synthesized neutral lipids were concentrated in LDs together with LD proteins. The LD formation was not abrogated by removal of medium glucose but was significantly inhibited by an ACSL inhibitor, triacsin C. These results demonstrate that long-chain fatty acids contribute to LD formation to a greater extent than glucose, possibly by being taken up into the cells, activated by ACSL, reconstituted into neutral lipids and then stored in LDs. Pregnenolone and lithium did not suppress oleic acid-dependent LD formation, despite previous reports of their ability to inhibit LD formation in macrophages and adipocytes suggesting differences among LD formations in these cells." @default.
• W2090085755 created "2016-06-24" @default.
• W2090085755 creator A5007788413 @default.
• W2090085755 creator A5019765787 @default.
• W2090085755 creator A5023918956 @default.
• W2090085755 creator A5031183787 @default.
• W2090085755 creator A5037584672 @default.
• W2090085755 creator A5038962300 @default.
• W2090085755 creator A5055255364 @default.
• W2090085755 creator A5058077731 @default.
• W2090085755 creator A5068643861 @default.
• W2090085755 creator A5068766545 @default.
• W2090085755 creator A5082470759 @default.
• W2090085755 date "2006-01-01" @default.
• W2090085755 modified "2023-10-14" @default.
• W2090085755 title "Long-Chain Fatty Acids Induce Lipid Droplet Formation in a Cultured Human Hepatocyte in a Manner Dependent of Acyl-CoA Synthetase" @default.
• W2090085755 cites W1913876816 @default.
• W2090085755 cites W1964917802 @default.
• W2090085755 cites W1965039157 @default.
• W2090085755 cites W1973958786 @default.
• W2090085755 cites W1984671783 @default.
• W2090085755 cites W1988657641 @default.
• W2090085755 cites W1990122690 @default.
• W2090085755 cites W199474707 @default.
• W2090085755 cites W2009683169 @default.
• W2090085755 cites W2019981157 @default.
• W2090085755 cites W2032401910 @default.
• W2090085755 cites W2041128061 @default.
• W2090085755 cites W2043129312 @default.
• W2090085755 cites W2043237666 @default.
• W2090085755 cites W2047856497 @default.
• W2090085755 cites W2052378749 @default.
• W2090085755 cites W2053150532 @default.
• W2090085755 cites W2053948748 @default.
• W2090085755 cites W2055432111 @default.
• W2090085755 cites W2059275312 @default.
• W2090085755 cites W2069029730 @default.
• W2090085755 cites W2073998126 @default.
• W2090085755 cites W2075727603 @default.
• W2090085755 cites W2089501938 @default.
• W2090085755 cites W2090943917 @default.
• W2090085755 cites W2093711908 @default.
• W2090085755 cites W2123180955 @default.
• W2090085755 cites W2160518844 @default.
• W2090085755 cites W2166446773 @default.
• W2090085755 cites W2183226167 @default.
• W2090085755 cites W4299365787 @default.
• W2090085755 doi "https://doi.org/10.1248/bpb.29.2174" @default.
• W2090085755 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17077510" @default.
• W2090085755 hasPublicationYear "2006" @default.
• W2090085755 type Work @default.
• W2090085755 sameAs 2090085755 @default.
• W2090085755 citedByCount "92" @default.
• W2090085755 countsByYear W20900857552012 @default.
• W2090085755 countsByYear W20900857552013 @default.
• W2090085755 countsByYear W20900857552014 @default.
• W2090085755 countsByYear W20900857552015 @default.
• W2090085755 countsByYear W20900857552016 @default.
• W2090085755 countsByYear W20900857552017 @default.
• W2090085755 countsByYear W20900857552018 @default.
• W2090085755 countsByYear W20900857552019 @default.
• W2090085755 countsByYear W20900857552020 @default.
• W2090085755 countsByYear W20900857552021 @default.
• W2090085755 countsByYear W20900857552022 @default.
• W2090085755 countsByYear W20900857552023 @default.
• W2090085755 crossrefType "journal-article" @default.
• W2090085755 hasAuthorship W2090085755A5007788413 @default.
• W2090085755 hasAuthorship W2090085755A5019765787 @default.
• W2090085755 hasAuthorship W2090085755A5023918956 @default.
• W2090085755 hasAuthorship W2090085755A5031183787 @default.
• W2090085755 hasAuthorship W2090085755A5037584672 @default.
• W2090085755 hasAuthorship W2090085755A5038962300 @default.
• W2090085755 hasAuthorship W2090085755A5055255364 @default.
• W2090085755 hasAuthorship W2090085755A5058077731 @default.
• W2090085755 hasAuthorship W2090085755A5068643861 @default.
• W2090085755 hasAuthorship W2090085755A5068766545 @default.
• W2090085755 hasAuthorship W2090085755A5082470759 @default.
• W2090085755 hasBestOaLocation W20900857551 @default.
• W2090085755 hasConcept C185592680 @default.
• W2090085755 hasConcept C202751555 @default.
• W2090085755 hasConcept C25095133 @default.
• W2090085755 hasConcept C2776200302 @default.
• W2090085755 hasConcept C2778918659 @default.
• W2090085755 hasConcept C2781403372 @default.
• W2090085755 hasConcept C41625074 @default.
• W2090085755 hasConcept C4733338 @default.
• W2090085755 hasConcept C543025807 @default.
• W2090085755 hasConcept C55493867 @default.
• W2090085755 hasConcept C79879829 @default.
• W2090085755 hasConcept C86803240 @default.
• W2090085755 hasConceptScore W2090085755C185592680 @default.
• W2090085755 hasConceptScore W2090085755C202751555 @default.
• W2090085755 hasConceptScore W2090085755C25095133 @default.
• W2090085755 hasConceptScore W2090085755C2776200302 @default.
• W2090085755 hasConceptScore W2090085755C2778918659 @default.
• W2090085755 hasConceptScore W2090085755C2781403372 @default.
• W2090085755 hasConceptScore W2090085755C41625074 @default.
• W2090085755 hasConceptScore W2090085755C4733338 @default.

• next