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• W2090089396 abstract "Tolcapone is a potent catechol-O-methyltransferase inhibitor that prolongs the plasma half-life of levodopa. This multicenter, double-blind, placebo-controlled study used two 10-hour clinical evaluations to compare the efficacy and safety of three doses of tolcapone (50, 200, and 400 mg tid) with placebo in patients with Parkinson9s disease (PD) experiencing motor fluctuations from levodopa/carbidopa. One hundred fifty-one patients completed the study. Clinical evaluations lasting 10 hours were performed on day -1 and day 42 using United Parkinson9s Disease Rating Scale motor subscale and on/off and dyskinesia assessments every 30 minutes. Tolcapone significantly reduced off time an average of 40% and increased total on time by about 25% at all dose levels, as compared to placebo treatment. Levodopa/carbidopa dosage and frequency were significantly reduced. Tolcapone was well tolerated, with patients experiencing typical dopaminergic side effects that could be reduced or eliminated by lowering levodopa/carbidopa dosages. Tolcapone was effective at prolonging the clinical benefit of levodopa and reducing total levodopa requirements in PD patients with motor fluctuations. <b>NEUROLOGY 1997;48: </b> 81-87" @default.
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• W2090089396 date "1997-01-01" @default.
• W2090089396 modified "2023-10-18" @default.
• W2090089396 title "Tolcapone Improves Motor Function and Reduces Levodopa Requirement in Patients with Parkinson's Disease Experiencing Motor Fluctuations: A Multicenter, Double-Blind, Randomized, Placebo-Controlled Trial" @default.
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• W2090089396 doi "https://doi.org/10.1212/wnl.48.1.81" @default.
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