Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090090086> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2090090086 endingPage "84" @default.
- W2090090086 startingPage "79" @default.
- W2090090086 abstract "Methoxymorpholinyl doxorubicin (MMDX) is a novel anti-cancer anthracycline that differs from doxorubicin in its mechanisms of action, pattern of resistance and metabolism. Whereas doxorubicin is primarily an inhibitor of topoisomerase II, MMDX inhibits both topoisomerases I and II, resulting in predominantly single-strand DNA cleavage and, to a lesser extent, double-strand DNA breakage. MMDX is equally cytotoxic in vitro against the doxorubicin-sensitive and -resistant uterine sarcoma cell lines, MES-SA and Dx5. Using fluorescent laser cytometry, MMDX was retained intracellularly to a similar extent in MES-SA and Dx5; the intracellular retention of MMDX was 7.5-fold higher than that of doxorubicin in Dx5. The cytotoxicity of MMDX on an ovarian carcinoma cell line, ES-2, was potentiated 50-fold by preincubating the drug with human liver microsomes and NADPH. This cytotoxic potentiation was associated with the appearance of DNA interstrand cross-links. The in vitro potentiation of MMDX was inhibited by cyclosporin A, which is a substrate for human cytochrome P450 IIIA." @default.
- W2090090086 created "2016-06-24" @default.
- W2090090086 creator A5019649110 @default.
- W2090090086 creator A5049738459 @default.
- W2090090086 creator A5070878175 @default.
- W2090090086 creator A5072180046 @default.
- W2090090086 date "1994-07-01" @default.
- W2090090086 modified "2023-10-18" @default.
- W2090090086 title "Metabolic conversion of methoxymorpholinyl doxorubicin: from a DNA strand breaker to a DNA cross-linker" @default.
- W2090090086 cites W1514384366 @default.
- W2090090086 cites W1884743999 @default.
- W2090090086 cites W1973876897 @default.
- W2090090086 cites W1982411138 @default.
- W2090090086 cites W1990961958 @default.
- W2090090086 cites W1997049293 @default.
- W2090090086 cites W2016254453 @default.
- W2090090086 cites W2020893327 @default.
- W2090090086 cites W2043703023 @default.
- W2090090086 cites W2056600059 @default.
- W2090090086 cites W2058872912 @default.
- W2090090086 cites W2072413519 @default.
- W2090090086 cites W2091509247 @default.
- W2090090086 cites W2093554313 @default.
- W2090090086 cites W2098105528 @default.
- W2090090086 cites W2102345056 @default.
- W2090090086 cites W2110246789 @default.
- W2090090086 cites W2112031278 @default.
- W2090090086 cites W2114918609 @default.
- W2090090086 cites W2120350646 @default.
- W2090090086 cites W2133602906 @default.
- W2090090086 cites W2615953705 @default.
- W2090090086 doi "https://doi.org/10.1038/bjc.1994.253" @default.
- W2090090086 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2033319" @default.
- W2090090086 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8018545" @default.
- W2090090086 hasPublicationYear "1994" @default.
- W2090090086 type Work @default.
- W2090090086 sameAs 2090090086 @default.
- W2090090086 citedByCount "24" @default.
- W2090090086 countsByYear W20900900862012 @default.
- W2090090086 countsByYear W20900900862017 @default.
- W2090090086 countsByYear W20900900862021 @default.
- W2090090086 crossrefType "journal-article" @default.
- W2090090086 hasAuthorship W2090090086A5019649110 @default.
- W2090090086 hasAuthorship W2090090086A5049738459 @default.
- W2090090086 hasAuthorship W2090090086A5070878175 @default.
- W2090090086 hasAuthorship W2090090086A5072180046 @default.
- W2090090086 hasBestOaLocation W20900900862 @default.
- W2090090086 hasConcept C109316439 @default.
- W2090090086 hasConcept C121608353 @default.
- W2090090086 hasConcept C147897179 @default.
- W2090090086 hasConcept C153911025 @default.
- W2090090086 hasConcept C154317977 @default.
- W2090090086 hasConcept C202751555 @default.
- W2090090086 hasConcept C2776694085 @default.
- W2090090086 hasConcept C2776802502 @default.
- W2090090086 hasConcept C2781303535 @default.
- W2090090086 hasConcept C530470458 @default.
- W2090090086 hasConcept C54355233 @default.
- W2090090086 hasConcept C552990157 @default.
- W2090090086 hasConcept C55493867 @default.
- W2090090086 hasConcept C86803240 @default.
- W2090090086 hasConceptScore W2090090086C109316439 @default.
- W2090090086 hasConceptScore W2090090086C121608353 @default.
- W2090090086 hasConceptScore W2090090086C147897179 @default.
- W2090090086 hasConceptScore W2090090086C153911025 @default.
- W2090090086 hasConceptScore W2090090086C154317977 @default.
- W2090090086 hasConceptScore W2090090086C202751555 @default.
- W2090090086 hasConceptScore W2090090086C2776694085 @default.
- W2090090086 hasConceptScore W2090090086C2776802502 @default.
- W2090090086 hasConceptScore W2090090086C2781303535 @default.
- W2090090086 hasConceptScore W2090090086C530470458 @default.
- W2090090086 hasConceptScore W2090090086C54355233 @default.
- W2090090086 hasConceptScore W2090090086C552990157 @default.
- W2090090086 hasConceptScore W2090090086C55493867 @default.
- W2090090086 hasConceptScore W2090090086C86803240 @default.
- W2090090086 hasIssue "1" @default.
- W2090090086 hasLocation W20900900861 @default.
- W2090090086 hasLocation W20900900862 @default.
- W2090090086 hasLocation W20900900863 @default.
- W2090090086 hasLocation W20900900864 @default.
- W2090090086 hasOpenAccess W2090090086 @default.
- W2090090086 hasPrimaryLocation W20900900861 @default.
- W2090090086 hasRelatedWork W1977410607 @default.
- W2090090086 hasRelatedWork W1981735895 @default.
- W2090090086 hasRelatedWork W2050829041 @default.
- W2090090086 hasRelatedWork W2082189979 @default.
- W2090090086 hasRelatedWork W2083262002 @default.
- W2090090086 hasRelatedWork W2413315576 @default.
- W2090090086 hasRelatedWork W2417592597 @default.
- W2090090086 hasRelatedWork W2494301268 @default.
- W2090090086 hasRelatedWork W2565796763 @default.
- W2090090086 hasRelatedWork W3184042829 @default.
- W2090090086 hasVolume "70" @default.
- W2090090086 isParatext "false" @default.
- W2090090086 isRetracted "false" @default.
- W2090090086 magId "2090090086" @default.
- W2090090086 workType "article" @default.