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• W2090095800 abstract "The behavioral inhibition system (BIS) and the behavioral activation system (BAS) are two fundamental motivational systems which are not only responsible for affective states, behavior and personality, but also related to predispositions for various forms of psychopathology. A wide range of previous studies revealed sex differences in both BIS/BAS and affective disorders (e.g., anxiety disorder) and externalizing disorders (e.g., addictive and impulsive behaviors), and a close link might exist between them. It remains to be clarified, however, whether the relationships between neuroanatomical characteristics and BIS/BAS exhibit sex differences. To investigate, voxel-based morphometry (VBM) was used to examine sex differences in the correlations between regional gray matter volume (rGMV) and scores on the Behavioral Inhibition System/Behavioral Activation System (BIS/BAS) scale in a large sample of healthy young adults (n = 353). Results showed that females displayed a negative correlation between BIS sensitivity and rGMV in the parahippocampal gyrus (PHG), as well as positive correlations between BAS sensitivity and rGMV in the ventromedial prefrontal cortex (vmPFC) and inferior parietal lobule (IPL), whereas males showed the opposite pattern. These findings suggest that the brain regions associated with processing of negative emotions (PHG) and reward-related information (vmPFC and IPL) may contribute to sex-related differences in rGMV correlates of BIS and BAS, respectively. The present findings demonstrated the evidence of sex-linked neuroanatomical background of BIS and BAS among non-clinical subjects and might encourage future research into the gender-specific relationships between BIS/BAS and related affective disorders and externalizing disorders." @default.
• W2090095800 created "2016-06-24" @default.
• W2090095800 creator A5010598908 @default.
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• W2090095800 creator A5040908867 @default.
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• W2090095800 creator A5087855437 @default.
• W2090095800 date "2014-11-01" @default.
• W2090095800 modified "2023-10-13" @default.
• W2090095800 title "Gender-specific neuroanatomical basis of behavioral inhibition/approach systems (BIS/BAS) in a large sample of young adults: A voxel-based morphometric investigation" @default.
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