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• W2090101322 abstract "S(-)-Satropane is currently being developed to in situ forming ophthalmic gel, a new ophthalmic delivery system, for the treatment of glaucoma. To evaluate the pharmacokinetic profiles of S(-)-satropane, the microdialysis method was employed. The concentration of S(-)-satropane in dialysates was measured by using liquid chromatography/tandem mass spectrometry (LC-MS/MS). Unlike the common solution prepared in normal saline, in which the level of S(-)-satropane in aqueous humor increased rapidly after instillation and reached the maximal level (C(max) of 1.508+/-0.297 microg ml(-1)) within 1h, S(-)-satropane exhibited 3.2-fold greater C(max) and 2.2-fold greater AUC(0-3h) (p<0.05) in the in situ forming gel. The results showed that the in situ forming gel system could improve the ocular bioavailability of S(-)-satropane." @default.
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• W2090101322 date "2008-11-01" @default.
• W2090101322 modified "2023-09-22" @default.
• W2090101322 title "Study of ocular pharmacokinetics of in situ gel system for S(−)-satropane evaluated by microdialysis" @default.
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• W2090101322 doi "https://doi.org/10.1016/j.jpba.2008.06.001" @default.
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