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- W2090102344 abstract "1-(4-Chlorophenyl)-4-{2-[342-pyridyl)acrylyloxy]ethyl}-piperazine (DA 1529) has been found the most active among 29 alkylpiperazine esters studied. Following oral administration, DA 1529 prevents the edema formation provoked in rats by subplantar injection of carrageenin, formalin, and dextran; it has antinociceptive effect on inflamed (not on normal) foot of rats; it has antipyretic effect in yeast-treated pyrexial rats. DA 1529 is as active or only a little less active than phenyl-butazone as anti-inflammatory; it is more active than phenylbutazone as analgesic and antipyretic. The acute toxicity in mice of DA 1529 is similar to that of phenylbutazone. DA 1529 has been found to possess mild CNS depressant properties as evidenced in mice by the results of the barbiturate potentiation test, of the rotarod test, by the reduced spontaneous motility, by analgesia in the hot-plate test, by the hypothermic effect." @default.
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- W2090102344 date "1966-10-01" @default.
- W2090102344 modified "2023-09-26" @default.
- W2090102344 title "Anti-Inflammatory and CNS dEpressant Properties of 1-(4-chlorophenyl)-4-{2-[3-(2-pyridyl) acrylyloxy]-ethyl}-piperazine (DA 1529)" @default.
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- W2090102344 doi "https://doi.org/10.1002/jps.2600551026" @default.
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