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- W2090111382 abstract "Randomized clinical trials of valaciclovir in recurrent herpes labialis are lacking.To determine whether a single course of valaciclovir, i.e. 500, 1000 or 2000 mg, administered during the prodrome of herpes facialis, could be beneficial.Three hundred and forty-five out-patients with herpes labialis were screened and randomized for a multicentre, double-blind clinical trial. Ninety-six patients had no recurrence after 6 months of follow-up; 249 patients were finally included in the intent-to-treat (ITT) population. The main outcome measure was the rate of aborted episodes at day 3. The three treatment groups were similar at baseline.There was no statistically significant difference between the groups in rates of aborted lesions at day 3 in the ITT population, in particular between the 500 mg and 2000 mg treatment groups.Although a placebo group was not included in this pilot study, a single dose of valaciclovir was not considered beneficial in patients with recurrent herpes facialis." @default.
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- W2090111382 date "2003-01-01" @default.
- W2090111382 modified "2023-09-26" @default.
- W2090111382 title "Valaciclovir as a single dose during prodrome of herpes facialis: a pilot randomized double-blind clinical trial" @default.
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- W2090111382 doi "https://doi.org/10.1046/j.1365-2133.2003.05062.x" @default.
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