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• W2090114495 abstract "We report a patient with Philadelphia chromosome positive (Ph +ve) chronic myelogenous leukemia (CML), treated with hydroxyurea alone, who upon disease progression developed an additional Ph - ve clone containing chromosomal abnormalities typical of myelodysplastic syndrome (MDS). Retrospective analysis of a cryopreserved stem cell specimen from diagnosis confirmed that this second clone developed during the course of treatment. The development of a clone with additional cytogenetic abnormalities in CML has only been reported after leukemogenic treatment, stem cell transplantation or interferon. We report a case of secondary Ph - ve MDS/AML during blast crisis in a patient treated with hydroxyurea for CML." @default.
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• W2090114495 date "2002-04-01" @default.
• W2090114495 modified "2023-09-23" @default.
• W2090114495 title "Coexistence of independent myelodysplastic and Philadelphia chromosome positive clones in a patient treated with hydroxyurea" @default.
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• W2090114495 doi "https://doi.org/10.1016/s0145-2126(01)00140-0" @default.
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