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- W2090118178 abstract "Abstract There is compelling evidence that Alzheimer's disease (AD) amyloid‐β (Aβ) deposition is associated with a local inflammatory response, which is initiated by the activation of microglia and the recruitment of astrocytes. These cells secrete a number of cytokines and neurotoxic products that may contribute to neuronal degeneration and cell death. It has been documented that long‐term intake of non‐steroidal anti‐inflammatory drugs (NSAIDs) decrease the risk for developing AD and delay the onset of the disease. The mechanism behind these NSAIDs is still controversial and several hypotheses have been raised, including changes in the amyloid precursor protein (APP) metabolism, in Aβ aggregation and a decrease in inflammatory mediators. Recently, it was proposed that some NSAIDs might activate the peroxisome proliferator‐activated receptor‐γ (PPAR‐γ). PPAR‐γ belongs to a family of nuclear receptors that are able to regulate the transcription of pro‐inflammatory molecules, such as iNOS. The activation of PPAR‐γ has been recently reported to reduce Aβ levels in cell culture and AD animal models. The implication of PPAR‐γ in the control of Aβ‐induced inflammation suggests a new target for AD therapy and emphasize the contribution of neuroinflammatory mechanisms to the pathogenesis of AD." @default.
- W2090118178 created "2016-06-24" @default.
- W2090118178 creator A5037328125 @default.
- W2090118178 creator A5078440867 @default.
- W2090118178 creator A5090943326 @default.
- W2090118178 date "2006-02-10" @default.
- W2090118178 modified "2023-10-15" @default.
- W2090118178 title "Contribution of inflammatory processes to Alzheimer's disease: molecular mechanisms" @default.
- W2090118178 cites W1485161311 @default.
- W2090118178 cites W1539079080 @default.
- W2090118178 cites W1542215809 @default.
- W2090118178 cites W1545110321 @default.
- W2090118178 cites W1558213119 @default.
- W2090118178 cites W1567490604 @default.
- W2090118178 cites W1639924204 @default.
- W2090118178 cites W1656162023 @default.
- W2090118178 cites W1657989568 @default.
- W2090118178 cites W1668456947 @default.
- W2090118178 cites W1672086017 @default.
- W2090118178 cites W1678111194 @default.
- W2090118178 cites W1868333091 @default.
- W2090118178 cites W1885605401 @default.
- W2090118178 cites W1966977299 @default.
- W2090118178 cites W1968703258 @default.
- W2090118178 cites W1969516175 @default.
- W2090118178 cites W1970055334 @default.
- W2090118178 cites W1973238388 @default.
- W2090118178 cites W1973531097 @default.
- W2090118178 cites W1973687314 @default.
- W2090118178 cites W1977666051 @default.
- W2090118178 cites W1978078908 @default.
- W2090118178 cites W1980574540 @default.
- W2090118178 cites W1982064952 @default.
- W2090118178 cites W1987319516 @default.
- W2090118178 cites W1988254695 @default.
- W2090118178 cites W1994925004 @default.
- W2090118178 cites W2001402586 @default.
- W2090118178 cites W2002519246 @default.
- W2090118178 cites W2010476270 @default.
- W2090118178 cites W2012983715 @default.
- W2090118178 cites W2015163544 @default.
- W2090118178 cites W2016443141 @default.
- W2090118178 cites W2022127378 @default.
- W2090118178 cites W2022730112 @default.
- W2090118178 cites W2025563134 @default.
- W2090118178 cites W2026453296 @default.
- W2090118178 cites W2029316374 @default.
- W2090118178 cites W2032161093 @default.
- W2090118178 cites W2032694200 @default.
- W2090118178 cites W2034066397 @default.
- W2090118178 cites W2037099926 @default.
- W2090118178 cites W2037257132 @default.
- W2090118178 cites W2038629104 @default.
- W2090118178 cites W2040389158 @default.
- W2090118178 cites W2042036635 @default.
- W2090118178 cites W2042584101 @default.
- W2090118178 cites W2044382297 @default.
- W2090118178 cites W2046454316 @default.
- W2090118178 cites W2048510554 @default.
- W2090118178 cites W2049623023 @default.
- W2090118178 cites W2055092854 @default.
- W2090118178 cites W2057365200 @default.
- W2090118178 cites W2059895383 @default.
- W2090118178 cites W2060274086 @default.
- W2090118178 cites W2063305853 @default.
- W2090118178 cites W2065742642 @default.
- W2090118178 cites W2068477037 @default.
- W2090118178 cites W2068932980 @default.
- W2090118178 cites W2070476305 @default.
- W2090118178 cites W2073420511 @default.
- W2090118178 cites W2075713420 @default.
- W2090118178 cites W2077290313 @default.
- W2090118178 cites W2080550827 @default.
- W2090118178 cites W2081219796 @default.
- W2090118178 cites W2082487815 @default.
- W2090118178 cites W2082708035 @default.
- W2090118178 cites W2083556882 @default.
- W2090118178 cites W2087763494 @default.
- W2090118178 cites W2088404163 @default.
- W2090118178 cites W2091551200 @default.
- W2090118178 cites W2093374391 @default.
- W2090118178 cites W2094272888 @default.
- W2090118178 cites W2095553819 @default.
- W2090118178 cites W2103071556 @default.
- W2090118178 cites W2103126689 @default.
- W2090118178 cites W2105091430 @default.
- W2090118178 cites W2107752044 @default.
- W2090118178 cites W2109759840 @default.
- W2090118178 cites W2109803055 @default.
- W2090118178 cites W2111425451 @default.
- W2090118178 cites W2113467168 @default.
- W2090118178 cites W2113690827 @default.
- W2090118178 cites W2113779343 @default.
- W2090118178 cites W2115650832 @default.
- W2090118178 cites W2116784956 @default.
- W2090118178 cites W2123405128 @default.
- W2090118178 cites W2123446167 @default.
- W2090118178 cites W2123722683 @default.