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• W2090121914 abstract "Time for primary review 28 days. The organization of any differentiated cell is not random but is the result of a dynamic integration of extracellular and intracellular signals. During the development of the heart, cardiac myocytes are round shaped cells that differentiate into a rod-shaped phenotype. During the different stages of commitment and morphogenesis, the myocyte organizes its internal structure by undergoing myofibrillogenesis. This process results in the precise arrangement of contractile elements, supporting cytoskeleton, and endoplasmic reticulum. Within the sarcolemma, specialized regions are defined for attachment to components of the extracellular matrix (ECM). This specialized site of the sarcolemma consists of the ECM—Receptor—Cytoskeleton complex (Fig. 1). These sites will integrate attachment to the ECM and the series of proteins necessary for the chemical and mechanical transmission of information. In this review, we will describe the evidence that indicates there is a specialization of the sarcolemma at the Z line for the clustering of various receptors for the ECM as well as the cytoskeleton.Fig. 1 A diagrammatic representation of the specialized regions of the sarcolemma. For cell—cell attachment, the extracellular regions of cadherin molecules exhibit homotypic binding while the cytoplasmic domains connect to catenins and actin. A variety of receptors including integrins and growth factors are found in a specialized region on the lateral margin of the myocyte at or near the Z band. Both complexes have direct associations with various signal transduction and cytoskeletal components. It appears that the lateral complexes are not associated with actin like the cadherin—catenin complex.During development of the embryonic heart, two specialized regions of the sarcolemma develop: (1) intercalated disks for cell—cell interaction and (2) ECM—integrin—cytoskeletal connections for cell—ECM contacts. The formation of these regions appears to be a coordinated expression of ECM components, cell surface receptors, and signaling proteins [1–5]. The localization … * Corresponding author. Tel.: +1-803-733-3115; fax: +1-803-733-1533 borg{at}med.sc.edu" @default.
• W2090121914 created "2016-06-24" @default.
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• W2090121914 date "2000-05-01" @default.
• W2090121914 modified "2023-10-01" @default.
• W2090121914 title "Specialization at the Z line of cardiac myocytes" @default.
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• W2090121914 doi "https://doi.org/10.1016/s0008-6363(99)00433-2" @default.
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