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- W2090146756 abstract "Background/Aims: The aim of this study was to assess the effect of early and chronic administration of a prostaglandin E1 analogue (misoprostol) in the prevention of liver fibrosis and portal hypertension. Methods: Liver fibrosis was induced by bile duct ligation. Controls had a sham operation. Bile-duct-ligated rats were divided into two groups: placebo (vehicle only) and misoprostol (10 μg/d by gavage) for 4 weeks after surgery. Liver fibrosis was assessed by the area of fibrosis (image analysis), liver hydroxyproline content and serum hyaluronate. Systemic and splanchnic hemodynamics were evaluated including spleno-renal shunt blood flow by the transit-time ultrasound technique. Results: Mean arterial pressure was significantly lower in the misoprostol group (p<0.01). There was an unexpected increase in fibrosis parameters in the misoprostol group compared to the placebo group, e.g. area of fibrosis: 9.5±4.0 vs 15.0±8.1% (p<0.05). Spleno-renal shunt blood flow was significantly higher in the misoprostol group than in the placebo group (4.6±3.7 vs 2.2±2.0 ml/min, p<0.05) while portal pressure was unchanged. Conclusions: The early and chronic administration of misoprostol enhances porto-collateral circulation blood flow and the development of liver fibrosis in bile-duct-ligated rats." @default.
- W2090146756 created "2016-06-24" @default.
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- W2090146756 date "1999-01-01" @default.
- W2090146756 modified "2023-10-18" @default.
- W2090146756 title "Long-term administration of PGE1 increases liver fibrosis and collateral blood flow in bile-duct-ligated rats" @default.
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- W2090146756 doi "https://doi.org/10.1016/s0168-8278(99)80009-9" @default.
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