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- W2090147115 abstract "Background Tricuspid annular plane systolic excursion ( TAPSE ) has emerged as a novel and reliable measure of right ventricular ( RV ) function. The purpose of this study was to determine the effect of pulmonary hypertension ( PH ) therapy on TAPSE in pediatric patients and compare TAPSE to other quantitative measures of RV function. Methods A retrospective review of medical records and echocardiograms of patients in the PH clinic from January 2011 to August 2013 was done. Echocardiograms were analyzed prior to initiation or addition of a PH drug and at least 8 weeks later. Following quantitative measures of RV function were compared: TAPSE , TAPSE age‐based z‐score, RV fractional area change ( RVFAC ), tricuspid annular S′, tricuspid inflow E/tricuspid annular E′ velocity ( TV E/E′), and RV myocardial performance index ( RVMPI ). Results Of the 37 patients included in this study (median age 0.6 years), 23 (62.2%) were treatment naive and others had a new PH drug added to their regimen at the time of the baseline echocardiogram. The median duration between the baseline and follow‐up echocardiogram was 8 (2–25) months. There was a significant improvement in TAPSE and TAPSE age‐based z‐score on the follow‐up echocardiogram. RVFAC , tricuspid S′, TV E/E′, and RVMPI did not show a statistically significant change. Conclusion In contrast to the other echocardiographic markers of RV function, TAPSE , and TAPSE age‐based z‐score significantly improve after initiation or addition of PH therapy and can be used for serial noninvasive monitoring of RV function in pediatric PH patients." @default.
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- W2090147115 date "2014-11-03" @default.
- W2090147115 modified "2023-09-27" @default.
- W2090147115 title "Improvement in Tricuspid Annular Plane Systolic Excursion with Pulmonary Hypertension Therapy in Pediatric Patients" @default.
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- W2090147115 doi "https://doi.org/10.1111/echo.12835" @default.
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