FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090147204> ?p ?o ?g. }

• W2090147204 endingPage "121" @default.
• W2090147204 startingPage "111" @default.
• W2090147204 abstract "Glucagon-like peptide 1 (GLP-1) and its analogue exendin-4 inhibit food intake, reduce blood glucose levels and increase blood pressure and heart rate by acting on GLP-1 receptors in many brain regions. Within the CNS, GLP-1 is produced only by preproglucagon (PPG) neurons. We suggest that PPG neurons mediate the central effects of GLP-1 by modulating sympathetic and vagal outflow. We therefore analysed the projections of PPG neurons to brain sites involved in autonomic control. In transgenic mice expressing yellow fluorescent protein (YFP) under the control of the PPG promoter, we assessed YFP-immunoreactive innervation using an anti-GFP antiserum and avidin-biotin-peroxidase. PPG neurons were intensely YFP-immunoreactive and axons could be easily discriminated from dendrites. YFP-immunoreactive cell bodies occurred primarily within the caudal nucleus tractus solitarius (NTS) with additional somata ventral to the hypoglossal nucleus, in raphé obscurus and in the intermediate reticular nucleus. The caudal NTS contained a dense network of dendrites, some of which extended into the area postrema. Immunoreactive axons were widespread throughout NTS, dorsal vagal nucleus and reticular nucleus with few in the hypoglossal nucleus and pyramids. The dorsomedial and paraventricular hypothalamic nuclei, ventrolateral periaqueductal grey and thalamic paraventricular nucleus exhibited heavy innervation. The area postrema, rostral ventrolateral medulla, pontine central grey, locus coeruleus/Barrington's nucleus, arcuate nucleus and the vascular organ of the lamina terminalis were moderately innervated. Only a few axons occurred in the amygdala and subfornical organ. Our results demonstrate that PPG neurons innervate primarily brain regions involved in autonomic control. Thus, central PPG neurons are ideally situated to modulate sympathetic and parasympathetic outflow through input at a variety of central sites. Our data also highlight that immunohistochemistry improves detection of neurons expressing YFP. Hence, animals in which specific populations of neurons have been genetically-modified to express fluorescent proteins are likely to prove ideal for anatomical studies." @default.
• W2090147204 created "2016-06-24" @default.
• W2090147204 creator A5002740985 @default.
• W2090147204 creator A5020444111 @default.
• W2090147204 creator A5026591169 @default.
• W2090147204 creator A5084732102 @default.
• W2090147204 date "2011-04-01" @default.
• W2090147204 modified "2023-09-29" @default.
• W2090147204 title "Preproglucagon neurons project widely to autonomic control areas in the mouse brain" @default.
• W2090147204 cites W1582182371 @default.
• W2090147204 cites W1966059930 @default.
• W2090147204 cites W1971585777 @default.
• W2090147204 cites W1974250392 @default.
• W2090147204 cites W1975756049 @default.
• W2090147204 cites W1986696484 @default.
• W2090147204 cites W1989616977 @default.
• W2090147204 cites W1994357469 @default.
• W2090147204 cites W1998882505 @default.
• W2090147204 cites W2001808016 @default.
• W2090147204 cites W2009053293 @default.
• W2090147204 cites W2013082477 @default.
• W2090147204 cites W2041624484 @default.
• W2090147204 cites W2048170411 @default.
• W2090147204 cites W2051926965 @default.
• W2090147204 cites W2054649558 @default.
• W2090147204 cites W2076140273 @default.
• W2090147204 cites W2080128749 @default.
• W2090147204 cites W2082052031 @default.
• W2090147204 cites W2084807086 @default.
• W2090147204 cites W2106036385 @default.
• W2090147204 cites W2117905450 @default.
• W2090147204 cites W2132573091 @default.
• W2090147204 cites W2132978000 @default.
• W2090147204 cites W2144288812 @default.
• W2090147204 cites W2144770678 @default.
• W2090147204 cites W2145781698 @default.
• W2090147204 cites W2152880048 @default.
• W2090147204 cites W2164739707 @default.
• W2090147204 cites W2229722529 @default.
• W2090147204 cites W4230178491 @default.
• W2090147204 cites W4239029020 @default.
• W2090147204 cites W4241263341 @default.
• W2090147204 doi "https://doi.org/10.1016/j.neuroscience.2011.02.023" @default.
• W2090147204 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4298012" @default.
• W2090147204 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21329743" @default.
• W2090147204 hasPublicationYear "2011" @default.
• W2090147204 type Work @default.
• W2090147204 sameAs 2090147204 @default.
• W2090147204 citedByCount "154" @default.
• W2090147204 countsByYear W20901472042012 @default.
• W2090147204 countsByYear W20901472042013 @default.
• W2090147204 countsByYear W20901472042014 @default.
• W2090147204 countsByYear W20901472042015 @default.
• W2090147204 countsByYear W20901472042016 @default.
• W2090147204 countsByYear W20901472042017 @default.
• W2090147204 countsByYear W20901472042018 @default.
• W2090147204 countsByYear W20901472042019 @default.
• W2090147204 countsByYear W20901472042020 @default.
• W2090147204 countsByYear W20901472042021 @default.
• W2090147204 countsByYear W20901472042022 @default.
• W2090147204 countsByYear W20901472042023 @default.
• W2090147204 crossrefType "journal-article" @default.
• W2090147204 hasAuthorship W2090147204A5002740985 @default.
• W2090147204 hasAuthorship W2090147204A5020444111 @default.
• W2090147204 hasAuthorship W2090147204A5026591169 @default.
• W2090147204 hasAuthorship W2090147204A5084732102 @default.
• W2090147204 hasBestOaLocation W20901472042 @default.
• W2090147204 hasConcept C105702510 @default.
• W2090147204 hasConcept C134018914 @default.
• W2090147204 hasConcept C169760540 @default.
• W2090147204 hasConcept C170493617 @default.
• W2090147204 hasConcept C17291353 @default.
• W2090147204 hasConcept C24566897 @default.
• W2090147204 hasConcept C24998067 @default.
• W2090147204 hasConcept C2775857624 @default.
• W2090147204 hasConcept C2775864247 @default.
• W2090147204 hasConcept C2776459250 @default.
• W2090147204 hasConcept C2777426569 @default.
• W2090147204 hasConcept C2777619780 @default.
• W2090147204 hasConcept C2777820223 @default.
• W2090147204 hasConcept C2778110749 @default.
• W2090147204 hasConcept C2779929655 @default.
• W2090147204 hasConcept C2780723820 @default.
• W2090147204 hasConcept C2781298622 @default.
• W2090147204 hasConcept C2781333164 @default.
• W2090147204 hasConcept C2781404750 @default.
• W2090147204 hasConcept C2908929049 @default.
• W2090147204 hasConcept C2909432713 @default.
• W2090147204 hasConcept C2910823151 @default.
• W2090147204 hasConcept C32610206 @default.
• W2090147204 hasConcept C33114225 @default.
• W2090147204 hasConcept C37000724 @default.
• W2090147204 hasConcept C529278444 @default.
• W2090147204 hasConcept C551621295 @default.
• W2090147204 hasConcept C552161191 @default.
• W2090147204 hasConcept C55493867 @default.
• W2090147204 hasConcept C84393581 @default.
• W2090147204 hasConcept C86803240 @default.

• next