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- W2090147884 abstract "Proteins resident in the inner nuclear membrane and underlying nuclear lamina form a network that regulates nuclear functions. This review highlights a prominent family of nuclear lamina proteins that carries the LAP2-emerin-MAN1-domain (LEM-D). LEM-D proteins share an ability to bind lamins and tether repressive chromatin at the nuclear periphery. The importance of this family is underscored by findings that loss of individual LEM-D proteins causes progressive, tissue-restricted diseases, known as laminopathies. Diverse functions of LEM-D proteins are linked to interactions with unique and overlapping partners including signal transduction effectors, transcription factors and architectural proteins. Recent investigations suggest that LEM-D proteins form hubs within the nuclear lamina that integrate external signals important for tissue homeostasis and maintenance of progenitor cell populations." @default.
- W2090147884 created "2016-06-24" @default.
- W2090147884 creator A5062932756 @default.
- W2090147884 creator A5071294132 @default.
- W2090147884 creator A5072480270 @default.
- W2090147884 date "2015-06-01" @default.
- W2090147884 modified "2023-09-23" @default.
- W2090147884 title "Networking in the nucleus: a spotlight on LEM-domain proteins" @default.
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- W2090147884 doi "https://doi.org/10.1016/j.ceb.2015.03.005" @default.
- W2090147884 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4522374" @default.
- W2090147884 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25863918" @default.
- W2090147884 hasPublicationYear "2015" @default.
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