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- W2090150963 endingPage "1248" @default.
- W2090150963 startingPage "1236" @default.
- W2090150963 abstract "Trypanosomes and leishmania, the causative agents of several tropical diseases, possess a unique redox metabolism which is based on trypanothione. The bis(glutathionyl)spermidine is the central thiol that delivers electrons for the synthesis of DNA precursors, the detoxification of hydroperoxides and other trypanothione-dependent pathways. Many of the reactions are mediated by tryparedoxin, a distant member of the thioredoxin protein family. Trypanothione is kept reduced by the parasite-specific flavoenzyme trypanothione reductase. Since glutathione reductases and thioredoxin reductases are missing, the reaction catalyzed by trypanothione reductase represents the only connection between the NADPH- and the thiol-based redox metabolisms. Thus, cellular thiol redox homeostasis is maintained by the biosynthesis and reduction of trypanothione. Nearly all proteins of the parasite-specific trypanothione metabolism have proved to be essential." @default.
- W2090150963 created "2016-06-24" @default.
- W2090150963 creator A5026701214 @default.
- W2090150963 creator A5053477937 @default.
- W2090150963 date "2008-11-01" @default.
- W2090150963 modified "2023-09-26" @default.
- W2090150963 title "Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism" @default.
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