Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090157734> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2090157734 endingPage "242" @default.
- W2090157734 startingPage "231" @default.
- W2090157734 abstract "Immunoliposomes have been prepared from lipid mixtures of dipalmitoylphosphatidylcholine, wheat germ phosphatidylinositol and a reactive lipid (the m-maleimidobenzoyl-N-hydroxysuccinimide derivative of dipalmitoylphosphatidylethanolamine) which was conjugated to the N-succinimidyl-S-acetylthioacetate (SATA) derivative of a monoclonal antibody (H17E2) raised to human placental alkaline phosphatase (PLAP). The immunoliposomes were prepared by the extrusion technique (VETs) and by reverse phase evaporation (REVs) and were found to effectively target to immobilised PLAP and to PLAP or PLAP-like enzyme on the surface of a tumour cell line (A431) using an ELISA and autoradiography. The extent of binding to immobilised PLAP was a function of immunoliposomal lipid concentration, the weight-average number of antibody molecules per liposome (Pw) and the liposome size. The effectiveness of methotrexate-loaded immunoliposomes in inhibiting the proliferation of A431 cells was investigated relative to equivalent levels of the free drug. The immunoliposomes prepared by the extrusion technique (VETs) inhibited growth of A431 cells but had no effect on the growth of a normal human fibroblastic cell line. Immunoliposomes prepared by reverse phase evaporation (REVs) were less effective in inhibiting A431 cell proliferation. The immunoliposomes probably enter the tumour cells largely by receptor-mediated endocytosis although other mechanisms of uptake cannot be excluded." @default.
- W2090157734 created "2016-06-24" @default.
- W2090157734 creator A5009151363 @default.
- W2090157734 creator A5059650943 @default.
- W2090157734 date "1993-11-01" @default.
- W2090157734 modified "2023-09-23" @default.
- W2090157734 title "The targeting of immunoliposomes to tumour cells (A431) and the effects of encapsulated methotrexate" @default.
- W2090157734 cites W1489298252 @default.
- W2090157734 cites W1677977398 @default.
- W2090157734 cites W1775749144 @default.
- W2090157734 cites W1965569089 @default.
- W2090157734 cites W1975186650 @default.
- W2090157734 cites W1981095084 @default.
- W2090157734 cites W1989744185 @default.
- W2090157734 cites W1999913114 @default.
- W2090157734 cites W2002027142 @default.
- W2090157734 cites W2006370393 @default.
- W2090157734 cites W2013657652 @default.
- W2090157734 cites W2016883923 @default.
- W2090157734 cites W2042849083 @default.
- W2090157734 cites W2044351697 @default.
- W2090157734 cites W2055770771 @default.
- W2090157734 cites W2063699611 @default.
- W2090157734 cites W2070910479 @default.
- W2090157734 cites W2076827752 @default.
- W2090157734 cites W2078188258 @default.
- W2090157734 cites W2089602319 @default.
- W2090157734 cites W2102838769 @default.
- W2090157734 cites W2114918609 @default.
- W2090157734 cites W2150675563 @default.
- W2090157734 cites W2156596286 @default.
- W2090157734 cites W2441981690 @default.
- W2090157734 doi "https://doi.org/10.1016/0005-2736(93)90254-w" @default.
- W2090157734 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8218324" @default.
- W2090157734 hasPublicationYear "1993" @default.
- W2090157734 type Work @default.
- W2090157734 sameAs 2090157734 @default.
- W2090157734 citedByCount "19" @default.
- W2090157734 countsByYear W20901577342012 @default.
- W2090157734 countsByYear W20901577342014 @default.
- W2090157734 countsByYear W20901577342015 @default.
- W2090157734 countsByYear W20901577342016 @default.
- W2090157734 countsByYear W20901577342022 @default.
- W2090157734 crossrefType "journal-article" @default.
- W2090157734 hasAuthorship W2090157734A5009151363 @default.
- W2090157734 hasAuthorship W2090157734A5059650943 @default.
- W2090157734 hasConcept C1491633281 @default.
- W2090157734 hasConcept C153911025 @default.
- W2090157734 hasConcept C159654299 @default.
- W2090157734 hasConcept C185154212 @default.
- W2090157734 hasConcept C185592680 @default.
- W2090157734 hasConcept C203014093 @default.
- W2090157734 hasConcept C28005876 @default.
- W2090157734 hasConcept C29537977 @default.
- W2090157734 hasConcept C47170353 @default.
- W2090157734 hasConcept C542903549 @default.
- W2090157734 hasConcept C54355233 @default.
- W2090157734 hasConcept C55493867 @default.
- W2090157734 hasConcept C67082663 @default.
- W2090157734 hasConcept C81885089 @default.
- W2090157734 hasConcept C86803240 @default.
- W2090157734 hasConceptScore W2090157734C1491633281 @default.
- W2090157734 hasConceptScore W2090157734C153911025 @default.
- W2090157734 hasConceptScore W2090157734C159654299 @default.
- W2090157734 hasConceptScore W2090157734C185154212 @default.
- W2090157734 hasConceptScore W2090157734C185592680 @default.
- W2090157734 hasConceptScore W2090157734C203014093 @default.
- W2090157734 hasConceptScore W2090157734C28005876 @default.
- W2090157734 hasConceptScore W2090157734C29537977 @default.
- W2090157734 hasConceptScore W2090157734C47170353 @default.
- W2090157734 hasConceptScore W2090157734C542903549 @default.
- W2090157734 hasConceptScore W2090157734C54355233 @default.
- W2090157734 hasConceptScore W2090157734C55493867 @default.
- W2090157734 hasConceptScore W2090157734C67082663 @default.
- W2090157734 hasConceptScore W2090157734C81885089 @default.
- W2090157734 hasConceptScore W2090157734C86803240 @default.
- W2090157734 hasIssue "2" @default.
- W2090157734 hasLocation W20901577341 @default.
- W2090157734 hasLocation W20901577342 @default.
- W2090157734 hasOpenAccess W2090157734 @default.
- W2090157734 hasPrimaryLocation W20901577341 @default.
- W2090157734 hasRelatedWork W1638912119 @default.
- W2090157734 hasRelatedWork W1948237075 @default.
- W2090157734 hasRelatedWork W1989568041 @default.
- W2090157734 hasRelatedWork W2009893540 @default.
- W2090157734 hasRelatedWork W2019334768 @default.
- W2090157734 hasRelatedWork W2087339674 @default.
- W2090157734 hasRelatedWork W2318910005 @default.
- W2090157734 hasRelatedWork W2717944 @default.
- W2090157734 hasRelatedWork W4313528174 @default.
- W2090157734 hasRelatedWork W4383620078 @default.
- W2090157734 hasVolume "1152" @default.
- W2090157734 isParatext "false" @default.
- W2090157734 isRetracted "false" @default.
- W2090157734 magId "2090157734" @default.
- W2090157734 workType "article" @default.