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- W2090165678 abstract "Please cite this paper as: Baum, Suter, Gerber, Tschanz, Buergy, Blank, Hlushchuk and Djonov (2010). VEGF-A Promotes Intussusceptive Angiogenesis in the Developing Chicken Chorioallantoic Membrane. Microcirculation17(6), 447–457. Objective: To assess the impact of vascular endothelial growth factor (VEGF) on intussusceptive angiogenesis. Methods and results: Polyurethane casts of the microvasculature of chicken chorioallantoic membrane (CAM) were prepared on embryonic days (E) 8, 10, 12, and 14. At light microscopy level, minute holes (<2 μm in diameter) and hollows (>2 μm) were observed in the casts. Transmission electron microscopy disclosed the minute holes to mainly represent transluminal pillars characteristic for intussusceptive angiogenesis. The numerical density of the holes/pillars was highest at an early (E8) and a late (E12–E14) stage. Only mRNA of VEGF-A-122 and VEGF-A-166 isoforms was detected in the CAM. The transcription rate of VEGF-A mRNA peaked on E8/9 and E12, while VEGF-A protein expression increased on E8/9 and E11/12 to rapidly decrease thereafter as determined by immunoblotting. At all time points investigated, VEGF-A immunohistochemical reactivity was restricted to cells of the chorionic epithelium in direct contact to the capillary plexus. When the VEGF-R-inhibitor PTK787/ZK222584 (0.1 mg/mL) was applied on E9 CAM, the microvasculature topology on E12 was similar to that on E10. Conclusions: The temporal course of intussusception corresponded to the expression of VEGF-A in CAM microvasculature. Inhibition of VEGF-signaling retarded intussusceptive-dependent capillary maturation. These data suggest that VEGF promotes intussusception." @default.
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- W2090165678 date "2010-05-01" @default.
- W2090165678 modified "2023-10-16" @default.
- W2090165678 title "VEGF-A promotes intussusceptive angiogenesis in the developing chicken chorioallantoic membrane" @default.
- W2090165678 doi "https://doi.org/10.1111/j.1549-8719.2010.00043.x" @default.
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