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• W2090166423 abstract "In the present analysis we dissect the idiotype repertoire, independently of haptenbinding specificity, by immunizing different strains of mice with cross-linked monoclonal anti-idiotopet antibodies against antibody B1-8. B1-8 is a monoclonal antibody with specificity for the hapten (4-hydroxy-3-nitro-phenyl)acetyl (NP) and carries a germ line gene-encoded variable region. The results demonstrate that the expression of B1-8 idiotopes and their association with eachother and with NP-binding specificity are strain-specific. Certain idiotopes are expressed on antibodies differing in antigen-binding specificity, whereas one of the idiotopes appears strictly associated with NP-binding antibodies. The genetic analysis provides strong evidence that the strain specificity of the idiotope repertoire is a result of V region polymorphism in the mouse." @default.
• W2090166423 created "2016-06-24" @default.
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• W2090166423 date "1982-01-01" @default.
• W2090166423 modified "2023-10-18" @default.
• W2090166423 title "The immune response against anti-idiotope antibodies. I. Induction of idiotope-bearing antibodies and analysis of the idiotope repertoire" @default.
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• W2090166423 doi "https://doi.org/10.1002/eji.1830121210" @default.
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