FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090168914> ?p ?o ?g. }

• W2090168914 endingPage "22204" @default.
• W2090168914 startingPage "22199" @default.
• W2090168914 abstract "The unique glycolytic metabolism of most solid tumors, known as the Warburg effect, is associated with resistance to apoptosis that enables cancer cells to survive. Dichloroacetate (DCA) is an anticancer agent that can reverse the Warburg effect by inhibiting a key enzyme in cancer cells, pyruvate dehydrogenase kinase (PDK), that is required for the process. DCA is currently not approved for cancer treatment in the USA. Here, we present the synthesis, characterization, and anticancer properties of c , t , c -[Pt(NH 3 ) 2 (O 2 CHCl 2 ) 2 Cl 2 ], mitaplatin, in which two DCA units are appended to the axial positions of a six-coordinate Pt(IV) center. The negative intracellular redox potential reduces the platinum to release cisplatin, a Pt(II) compound, and two equivalents of DCA. By a unique mechanism, mitaplatin thereby attacks both nuclear DNA with cisplatin and mitochondria with DCA selectively in cancer cells. The cytotoxicity of mitaplatin in a variety of cancer cell lines equals or exceeds that of all known Pt(IV) compounds and is comparable to that of cisplatin. Mitaplatin alters the mitochondrial membrane potential gradient (Δψ m ) of cancer cells, promoting apoptosis by releasing cytochrome c and translocating apoptosis inducing factor from mitochondria to the nucleus. Cisplatin formed upon cellular reduction of mitaplatin enters the nucleus and targets DNA to form 1,2-intrastrand d(GpG) cross-links characteristic of its own potency as an anticancer drug. These properties of mitaplatin are manifest in its ability to selectively kill cancer cells cocultured with normal fibroblasts and to partially overcome cisplatin resistance." @default.
• W2090168914 created "2016-06-24" @default.
• W2090168914 creator A5024358551 @default.
• W2090168914 creator A5034625027 @default.
• W2090168914 date "2009-12-29" @default.
• W2090168914 modified "2023-10-11" @default.
• W2090168914 title "Mitaplatin, a potent fusion of cisplatin and the orphan drug dichloroacetate" @default.
• W2090168914 cites W1751026903 @default.
• W2090168914 cites W1964317310 @default.
• W2090168914 cites W1965672573 @default.
• W2090168914 cites W1972430178 @default.
• W2090168914 cites W1974693247 @default.
• W2090168914 cites W1994148625 @default.
• W2090168914 cites W2012108057 @default.
• W2090168914 cites W2012733189 @default.
• W2090168914 cites W2020316909 @default.
• W2090168914 cites W2033556029 @default.
• W2090168914 cites W2034269086 @default.
• W2090168914 cites W2042108437 @default.
• W2090168914 cites W2043610941 @default.
• W2090168914 cites W2068797007 @default.
• W2090168914 cites W2069206405 @default.
• W2090168914 cites W2072166383 @default.
• W2090168914 cites W2072451938 @default.
• W2090168914 cites W2074365586 @default.
• W2090168914 cites W2077998026 @default.
• W2090168914 cites W2087900954 @default.
• W2090168914 cites W2092787533 @default.
• W2090168914 cites W2097104496 @default.
• W2090168914 cites W2107344128 @default.
• W2090168914 cites W2115309273 @default.
• W2090168914 cites W2122028337 @default.
• W2090168914 cites W2123671636 @default.
• W2090168914 cites W2129360146 @default.
• W2090168914 cites W2129898733 @default.
• W2090168914 cites W2130503287 @default.
• W2090168914 cites W2132955042 @default.
• W2090168914 cites W2139808463 @default.
• W2090168914 cites W2148603246 @default.
• W2090168914 cites W2149279554 @default.
• W2090168914 cites W2149755406 @default.
• W2090168914 cites W2151260260 @default.
• W2090168914 cites W2158305374 @default.
• W2090168914 cites W2163650289 @default.
• W2090168914 cites W2164277862 @default.
• W2090168914 doi "https://doi.org/10.1073/pnas.0912276106" @default.
• W2090168914 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2799774" @default.
• W2090168914 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20007777" @default.
• W2090168914 hasPublicationYear "2009" @default.
• W2090168914 type Work @default.
• W2090168914 sameAs 2090168914 @default.
• W2090168914 citedByCount "322" @default.
• W2090168914 countsByYear W20901689142012 @default.
• W2090168914 countsByYear W20901689142013 @default.
• W2090168914 countsByYear W20901689142014 @default.
• W2090168914 countsByYear W20901689142015 @default.
• W2090168914 countsByYear W20901689142016 @default.
• W2090168914 countsByYear W20901689142017 @default.
• W2090168914 countsByYear W20901689142018 @default.
• W2090168914 countsByYear W20901689142019 @default.
• W2090168914 countsByYear W20901689142020 @default.
• W2090168914 countsByYear W20901689142021 @default.
• W2090168914 countsByYear W20901689142022 @default.
• W2090168914 countsByYear W20901689142023 @default.
• W2090168914 crossrefType "journal-article" @default.
• W2090168914 hasAuthorship W2090168914A5024358551 @default.
• W2090168914 hasAuthorship W2090168914A5034625027 @default.
• W2090168914 hasBestOaLocation W20901689142 @default.
• W2090168914 hasConcept C109156525 @default.
• W2090168914 hasConcept C109316439 @default.
• W2090168914 hasConcept C121608353 @default.
• W2090168914 hasConcept C153911025 @default.
• W2090168914 hasConcept C181199279 @default.
• W2090168914 hasConcept C185592680 @default.
• W2090168914 hasConcept C190283241 @default.
• W2090168914 hasConcept C20251656 @default.
• W2090168914 hasConcept C202751555 @default.
• W2090168914 hasConcept C2776694085 @default.
• W2090168914 hasConcept C2778239845 @default.
• W2090168914 hasConcept C28859421 @default.
• W2090168914 hasConcept C29311851 @default.
• W2090168914 hasConcept C31573885 @default.
• W2090168914 hasConcept C502942594 @default.
• W2090168914 hasConcept C54355233 @default.
• W2090168914 hasConcept C55493867 @default.
• W2090168914 hasConcept C86803240 @default.
• W2090168914 hasConcept C96232424 @default.
• W2090168914 hasConceptScore W2090168914C109156525 @default.
• W2090168914 hasConceptScore W2090168914C109316439 @default.
• W2090168914 hasConceptScore W2090168914C121608353 @default.
• W2090168914 hasConceptScore W2090168914C153911025 @default.
• W2090168914 hasConceptScore W2090168914C181199279 @default.
• W2090168914 hasConceptScore W2090168914C185592680 @default.
• W2090168914 hasConceptScore W2090168914C190283241 @default.
• W2090168914 hasConceptScore W2090168914C20251656 @default.
• W2090168914 hasConceptScore W2090168914C202751555 @default.
• W2090168914 hasConceptScore W2090168914C2776694085 @default.
• W2090168914 hasConceptScore W2090168914C2778239845 @default.

• next