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- W2090169401 abstract "► The thermo-sensitivity of poly( l -lactide)- g -pullulan (PLP) copolymers was investigated. ► PLP copolymers form self-organized nanogels consisting of hydrophobic cores of poly( l -lactide) and hydrophilic outer-shells of pullulan in an aqueous environment. ► Lactide substitution degree to the pullulan backbone affects the phase-transition temperature of PLP. ► The thermoresponsive system release more drug amount with temperature increase, resulting in effectively killing cancer cells. Thermo-responsive nanogels from poly( l -lactide)- g -pullulan (PLP1 and 2) copolymers with different lactide contents were investigated as an anticancer drug delivery carrier. The phase transition temperature of PLP 1 with lower lactide content in distilled water showed around 35 °C. Upon adding 0.15 M NaCl to PLP 1, a significant difference in the transmittance was observed when comparing the non-additive salt condition. The total amount of released doxorubicin (DOX) from the DOX-loaded PLP nanogels increased with increasing temperature for 50 h. A noticeable difference in the initial release by PLP 1 was observed between 37 and 42 °C. In the 50% inhibitory concentration (IC 50 ) analysis, the IC 50 values of DOX released from PLP 1 were approximately 5.9 and 9.3 μg/mL at 37 and 42 °C, respectively. The results suggest that self-assembled PLP nanogels, by means of a triggering temperature, can be used as a long-term drug delivery system in cancer treatments." @default.
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- W2090169401 date "2012-01-01" @default.
- W2090169401 modified "2023-09-30" @default.
- W2090169401 title "Thermo-sensitivity and triggered drug release of polysaccharide nanogels derived from pullulan-g-poly(l-lactide) copolymers" @default.
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- W2090169401 doi "https://doi.org/10.1016/j.carbpol.2011.08.061" @default.
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