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- W2090175904 abstract "Objective: To compile information of the type of Congenital Heart Disease (CHD), the concomitant presence of extra-cardiac structural defect and chromosomal abnormality in our center to assist patient counseling. The true positive rate (TPR) and positive predictive value (PPV) of the prenatal screening of various CHD is calculated. Methods: A single center, prospective, cross-sectional observational study of screening scans on low risk patients. A search of all the cases with CHDs from June 1996 to May 1999 yield a total of 226 cases of confirmed CHDs identified by postmortem examinations, surgery or neonatal 2D echocardiography. Results: The commonest defect is ventricular septal defect (VSD) and/or atrial septal defect (ASD) (75 cases), followed by Fallot's tetralogy/double outlet right ventricle (DORV) (31), pulmonary stenosis/atresia (14), hypoplastic left heart (12), tubular hypoplasia (9), atrio–ventricular septal defect (AVSD) (8) and Ebstein anomaly (8). The TPR differ for individual defect, ranging from 100% for hypoplastic left heart, hypoplastic right heart and Ebstein anomaly to 0% for truncus arteriosus and tubular hypoplasia. The PPV vary for the individual defects, ranging from 100% for Ebstein anomaly, coarctation of aorta, pulmonary stenosis, atrial septal defect and single ventricle to 0% for truncus arteriosus. The presence of a prenatally diagnosed CHD is associated with an increased risk of chromosomal abnormalities from 85.7% for AVSD and 57.1% for coarctation of aorta to 14.3% for Ebstein anomaly. Extra-cardiac defects are common in fetuses with chromosomal disorder. Conclusion: CHD is the commonest defect in the fetus and should be routinely screened for. Availability of de facto information in a diagnostic center is essential to help the mothers to come to an informed decision. Karyotyping should be routinely offered. Extra-cardiac lesions are common associations and should be carefully looked for. An acceptable positive predictive value is particularly important in post-screening counseling." @default.
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- W2090175904 date "2001-10-01" @default.
- W2090175904 modified "2023-09-24" @default.
- W2090175904 title "Prenatal diagnosis of congenital heart disease in a low risk obstetrics population in Singapore" @default.
- W2090175904 doi "https://doi.org/10.1046/j.1469-0705.2001.0180s1012.x" @default.
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