FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090184061> ?p ?o ?g. }

• W2090184061 endingPage "e6212" @default.
• W2090184061 startingPage "e6212" @default.
• W2090184061 abstract "Despite significant improvements in life expectancy of kidney transplant patients due to advances in surgery and immunosuppression, Chronic Allograft Nephropathy (CAN) remains a daunting problem. A complex network of cellular mechanisms in both graft and peripheral immune compartments complicates the non-invasive diagnosis of CAN, which still requires biopsy histology. This is compounded by non-immunological factors contributing to graft injury. There is a pressing need to identify and validate minimally invasive biomarkers for CAN to serve as early predictors of graft loss and as metrics for managing long-term immunosuppression.We used DNA microarrays, tandem mass spectroscopy proteomics and bioinformatics to identify genomic and proteomic markers of mild and moderate/severe CAN in peripheral blood of two distinct cohorts (n = 77 total) of kidney transplant patients with biopsy-documented histology.Gene expression profiles reveal over 2400 genes for mild CAN, and over 700 for moderate/severe CAN. A consensus analysis reveals 393 (mild) and 63 (moderate/severe) final candidates as CAN markers with predictive accuracy of 80% (mild) and 92% (moderate/severe). Proteomic profiles show over 500 candidates each, for both stages of CAN including 302 proteins unique to mild and 509 unique to moderate/severe CAN.This study identifies several unique signatures of transcript and protein biomarkers with high predictive accuracies for mild and moderate/severe CAN, the most common cause of late allograft failure. These biomarkers are the necessary first step to a proteogenomic classification of CAN based on peripheral blood profiling and will be the targets of a prospective clinical validation study." @default.
• W2090184061 created "2016-06-24" @default.
• W2090184061 creator A5000192581 @default.
• W2090184061 creator A5009852306 @default.
• W2090184061 creator A5013243779 @default.
• W2090184061 creator A5015379104 @default.
• W2090184061 creator A5023193798 @default.
• W2090184061 creator A5031361996 @default.
• W2090184061 creator A5037670410 @default.
• W2090184061 creator A5043885219 @default.
• W2090184061 creator A5048178172 @default.
• W2090184061 creator A5053275663 @default.
• W2090184061 creator A5054084920 @default.
• W2090184061 creator A5055451309 @default.
• W2090184061 creator A5058092094 @default.
• W2090184061 creator A5063644693 @default.
• W2090184061 creator A5066036858 @default.
• W2090184061 creator A5067036827 @default.
• W2090184061 creator A5070402874 @default.
• W2090184061 creator A5074700375 @default.
• W2090184061 creator A5081813028 @default.
• W2090184061 creator A5083768832 @default.
• W2090184061 creator A5087062032 @default.
• W2090184061 date "2009-07-10" @default.
• W2090184061 modified "2023-10-06" @default.
• W2090184061 title "Biomarkers for Early and Late Stage Chronic Allograft Nephropathy by Proteogenomic Profiling of Peripheral Blood" @default.
• W2090184061 cites W1597678601 @default.
• W2090184061 cites W1966701961 @default.
• W2090184061 cites W1973645636 @default.
• W2090184061 cites W1988875944 @default.
• W2090184061 cites W1990299806 @default.
• W2090184061 cites W1991100846 @default.
• W2090184061 cites W1993448656 @default.
• W2090184061 cites W1995791071 @default.
• W2090184061 cites W1997504014 @default.
• W2090184061 cites W1999969187 @default.
• W2090184061 cites W2005720848 @default.
• W2090184061 cites W2008161741 @default.
• W2090184061 cites W2012036801 @default.
• W2090184061 cites W2016605939 @default.
• W2090184061 cites W2019012138 @default.
• W2090184061 cites W2020586264 @default.
• W2090184061 cites W2020837846 @default.
• W2090184061 cites W2026939478 @default.
• W2090184061 cites W2029805256 @default.
• W2090184061 cites W2038732581 @default.
• W2090184061 cites W2044737323 @default.
• W2090184061 cites W2046944378 @default.
• W2090184061 cites W2055052061 @default.
• W2090184061 cites W2068806064 @default.
• W2090184061 cites W2072583817 @default.
• W2090184061 cites W2098173664 @default.
• W2090184061 cites W2098403120 @default.
• W2090184061 cites W2098773501 @default.
• W2090184061 cites W2098974363 @default.
• W2090184061 cites W2100203914 @default.
• W2090184061 cites W2112251064 @default.
• W2090184061 cites W2115487088 @default.
• W2090184061 cites W2120865735 @default.
• W2090184061 cites W2138620116 @default.
• W2090184061 cites W2148001303 @default.
• W2090184061 cites W2150926065 @default.
• W2090184061 cites W2155423555 @default.
• W2090184061 cites W2339009088 @default.
• W2090184061 cites W2466989261 @default.
• W2090184061 doi "https://doi.org/10.1371/journal.pone.0006212" @default.
• W2090184061 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2703807" @default.
• W2090184061 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19593431" @default.
• W2090184061 hasPublicationYear "2009" @default.
• W2090184061 type Work @default.
• W2090184061 sameAs 2090184061 @default.
• W2090184061 citedByCount "74" @default.
• W2090184061 countsByYear W20901840612012 @default.
• W2090184061 countsByYear W20901840612013 @default.
• W2090184061 countsByYear W20901840612014 @default.
• W2090184061 countsByYear W20901840612015 @default.
• W2090184061 countsByYear W20901840612016 @default.
• W2090184061 countsByYear W20901840612017 @default.
• W2090184061 countsByYear W20901840612018 @default.
• W2090184061 countsByYear W20901840612019 @default.
• W2090184061 countsByYear W20901840612020 @default.
• W2090184061 countsByYear W20901840612021 @default.
• W2090184061 countsByYear W20901840612023 @default.
• W2090184061 crossrefType "journal-article" @default.
• W2090184061 hasAuthorship W2090184061A5000192581 @default.
• W2090184061 hasAuthorship W2090184061A5009852306 @default.
• W2090184061 hasAuthorship W2090184061A5013243779 @default.
• W2090184061 hasAuthorship W2090184061A5015379104 @default.
• W2090184061 hasAuthorship W2090184061A5023193798 @default.
• W2090184061 hasAuthorship W2090184061A5031361996 @default.
• W2090184061 hasAuthorship W2090184061A5037670410 @default.
• W2090184061 hasAuthorship W2090184061A5043885219 @default.
• W2090184061 hasAuthorship W2090184061A5048178172 @default.
• W2090184061 hasAuthorship W2090184061A5053275663 @default.
• W2090184061 hasAuthorship W2090184061A5054084920 @default.
• W2090184061 hasAuthorship W2090184061A5055451309 @default.
• W2090184061 hasAuthorship W2090184061A5058092094 @default.
• W2090184061 hasAuthorship W2090184061A5063644693 @default.

• next