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- W2090190799 abstract "Drug addiction is a compulsive behavioral abnormality. In spite of pharmacologic and psychosocial treatments to reduce or eliminate drug taking, addiction tends to persist over time. Preclinical and human observations have converged on the hypothesis that addiction represents the pathologic deterioration of neural processes that normally serve affective and cognitive functioning. The major elements of persistent compulsive drug use are hypothesized to be molecular and cellular mechanisms that underlie enduring changes in a number of forebrain circuits (involving the ventral striatum and prefrontal cortex) that receive input from midbrain dopamine neurons and are involved in affective and cognitive mechanisms, respectively. Here we review progress in identifying crucial elements useful in understanding the pathophysiology of the disease and its pharmacologic treatment. Pharmacologic targeting of K-opiate receptors, with their discrete distribution within the dopaminergic system(s), and thus different actions on dopaminoceptive areas, may provide beneficial effects at the affective and cognitive level." @default.
- W2090190799 created "2016-06-24" @default.
- W2090190799 creator A5012224844 @default.
- W2090190799 creator A5068049084 @default.
- W2090190799 creator A5088344715 @default.
- W2090190799 date "2008-10-01" @default.
- W2090190799 modified "2023-10-01" @default.
- W2090190799 title "Addiction and Cognitive Functions" @default.
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- W2090190799 doi "https://doi.org/10.1196/annals.1432.008" @default.
- W2090190799 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18991875" @default.
- W2090190799 hasPublicationYear "2008" @default.
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