FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090196544> ?p ?o ?g. }

• W2090196544 endingPage "132" @default.
• W2090196544 startingPage "119" @default.
• W2090196544 abstract "Elastolysis, collagenolysis and gelatinolysis are essential in the pathogenesis of tobacco smoke-induced emphysema; however, these activities have been scantily studied in emphysema secondary to woodsmoke. The aim of this study was to analyze elastolysis, collagenolysis and gelatinolysis, MMP-1, MMP-2, and MMP-9 expression, and apoptosis in guinea pigs exposed to smoke produced by 60 g/day of pine wood, 5 days/week, from 1 to 7 months. Histological analysis after 4 to 7 months in smoke exposed guinea pigs showed alveolar mononuclear phagocyte and lymphocytic peribronchiolar inflammation, epithelial and smooth muscle hyperplasia, and pulmonary arterial hypertension. Mild to moderate emphysematous lesions were observed in woodsmoke-exposed animals at 4 to 7 months by increase of mean linear intercepts. A higher percentage of whole blood carboxyhemoglobin (COHb) and elastolytic activity in bronchoalveolar lavage macrophages and lung tissue homogenates was observed at all times. Collagenolysis was increased after 4 to 7 months in woodsmoke-exposed animals, although collagen concentration did not change. Zymography revealed increase in lysis bands of the active MMP-2 and MMP-9 at 4 and 7 months in bronchoalveolar lavage fluid and lung tissue homogenate. Positive immunostaining for MMP-1 and MMP-9 was observed in epithelial cells and macrophages in wood exposed animals at 4 to 7 months. Real-time PCR showed MMP-2 and MMP-9 expression at 3 to 7 months in exposed animals. Furthermore, apoptosis was increased at all times in bronchoalveolar lavage macrophages and lung tissue from exposed animals. Results support a role of metalloproteinases and apoptosis in emphysema secondary to woodsmoke exposure." @default.
• W2090196544 created "2016-06-24" @default.
• W2090196544 creator A5036149666 @default.
• W2090196544 creator A5038192492 @default.
• W2090196544 creator A5049668922 @default.
• W2090196544 creator A5051373766 @default.
• W2090196544 creator A5055935456 @default.
• W2090196544 creator A5072554628 @default.
• W2090196544 date "2009-02-01" @default.
• W2090196544 modified "2023-09-28" @default.
• W2090196544 title "Increase of Matrix Metalloproteinases in Woodsmoke-Induced Lung Emphysema in Guinea Pigs" @default.
• W2090196544 cites W1517654177 @default.
• W2090196544 cites W170566225 @default.
• W2090196544 cites W1870141733 @default.
• W2090196544 cites W1973996480 @default.
• W2090196544 cites W1979558674 @default.
• W2090196544 cites W1980761600 @default.
• W2090196544 cites W1987045278 @default.
• W2090196544 cites W2000643722 @default.
• W2090196544 cites W2005589576 @default.
• W2090196544 cites W2006684806 @default.
• W2090196544 cites W2012112479 @default.
• W2090196544 cites W2018695645 @default.
• W2090196544 cites W2022934710 @default.
• W2090196544 cites W2025800319 @default.
• W2090196544 cites W2032103967 @default.
• W2090196544 cites W2043477365 @default.
• W2090196544 cites W2101182707 @default.
• W2090196544 cites W2103667291 @default.
• W2090196544 cites W2106629880 @default.
• W2090196544 cites W2108548041 @default.
• W2090196544 cites W2110499503 @default.
• W2090196544 cites W2114585886 @default.
• W2090196544 cites W2125828034 @default.
• W2090196544 cites W2127823826 @default.
• W2090196544 cites W2128571455 @default.
• W2090196544 cites W2137064182 @default.
• W2090196544 cites W2151651811 @default.
• W2090196544 cites W2154431017 @default.
• W2090196544 cites W2155478916 @default.
• W2090196544 cites W2157474797 @default.
• W2090196544 cites W2158026075 @default.
• W2090196544 cites W2161334641 @default.
• W2090196544 cites W2166432084 @default.
• W2090196544 cites W2189482669 @default.
• W2090196544 doi "https://doi.org/10.1080/08958370802419145" @default.
• W2090196544 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18836920" @default.
• W2090196544 hasPublicationYear "2009" @default.
• W2090196544 type Work @default.
• W2090196544 sameAs 2090196544 @default.
• W2090196544 citedByCount "25" @default.
• W2090196544 countsByYear W20901965442012 @default.
• W2090196544 countsByYear W20901965442013 @default.
• W2090196544 countsByYear W20901965442014 @default.
• W2090196544 countsByYear W20901965442015 @default.
• W2090196544 countsByYear W20901965442016 @default.
• W2090196544 countsByYear W20901965442017 @default.
• W2090196544 countsByYear W20901965442018 @default.
• W2090196544 countsByYear W20901965442019 @default.
• W2090196544 countsByYear W20901965442020 @default.
• W2090196544 countsByYear W20901965442021 @default.
• W2090196544 countsByYear W20901965442022 @default.
• W2090196544 countsByYear W20901965442023 @default.
• W2090196544 crossrefType "journal-article" @default.
• W2090196544 hasAuthorship W2090196544A5036149666 @default.
• W2090196544 hasAuthorship W2090196544A5038192492 @default.
• W2090196544 hasAuthorship W2090196544A5049668922 @default.
• W2090196544 hasAuthorship W2090196544A5051373766 @default.
• W2090196544 hasAuthorship W2090196544A5055935456 @default.
• W2090196544 hasAuthorship W2090196544A5072554628 @default.
• W2090196544 hasConcept C109523444 @default.
• W2090196544 hasConcept C126322002 @default.
• W2090196544 hasConcept C142724271 @default.
• W2090196544 hasConcept C161790260 @default.
• W2090196544 hasConcept C185592680 @default.
• W2090196544 hasConcept C2776378800 @default.
• W2090196544 hasConcept C2777714996 @default.
• W2090196544 hasConcept C2777961210 @default.
• W2090196544 hasConcept C512735826 @default.
• W2090196544 hasConcept C55493867 @default.
• W2090196544 hasConcept C71924100 @default.
• W2090196544 hasConceptScore W2090196544C109523444 @default.
• W2090196544 hasConceptScore W2090196544C126322002 @default.
• W2090196544 hasConceptScore W2090196544C142724271 @default.
• W2090196544 hasConceptScore W2090196544C161790260 @default.
• W2090196544 hasConceptScore W2090196544C185592680 @default.
• W2090196544 hasConceptScore W2090196544C2776378800 @default.
• W2090196544 hasConceptScore W2090196544C2777714996 @default.
• W2090196544 hasConceptScore W2090196544C2777961210 @default.
• W2090196544 hasConceptScore W2090196544C512735826 @default.
• W2090196544 hasConceptScore W2090196544C55493867 @default.
• W2090196544 hasConceptScore W2090196544C71924100 @default.
• W2090196544 hasIssue "2" @default.
• W2090196544 hasLocation W20901965441 @default.
• W2090196544 hasLocation W20901965442 @default.
• W2090196544 hasOpenAccess W2090196544 @default.
• W2090196544 hasPrimaryLocation W20901965441 @default.
• W2090196544 hasRelatedWork W1998429617 @default.

• next