Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090201519> ?p ?o ?g. }
- W2090201519 endingPage "86" @default.
- W2090201519 startingPage "79" @default.
- W2090201519 abstract "Metabolism of the colonic mucosa of patients with ulcerative colitis (UC; n=31) and Crohn's disease (CD; n=26) and normal mucosa (control, n=26) was investigated using in vitro high-resolution proton magnetic resonance spectroscopy. Of the 31 UC patients, 20 were in the active phase and 11 were in the remission phase of the disease. Out of 26 CD patients, 20 were in the active phase, while 6 were in the remission phase of the disease. Twenty-nine metabolites were assigned unambiguously in the perchloric acid extract of colonic mucosa. In the active phase of UC and CD, significantly lower (P<or=.05) concentration of amino acids (isoleucine, leucine, valine, alanine, glutamate and glutamine), membrane components (choline, glycerophosphorylcholine and myo-inositol), lactate and succinate were observed compared to normal mucosa of controls. Patients in the active phase of UC and CD also showed increased level of alpha-glucose compared to normal mucosa. Altered level of metabolites indicates decreased protein and carbohydrate metabolism, thereby decreased energy status and deterioration of mucosa integrity during chronic inflammation. In the remission phase of UC and CD, the concentration of most of the metabolites was similar to controls except for lower values of lactate, glycerophosphorylcholine and myo-inositol in UC and Lac in CD. Formate was significantly lower in patients with the active phase of UC compared to patients with the active phase of CD, suggesting the potential of in vitro MRS in the differentiation of these two diseases." @default.
- W2090201519 created "2016-06-24" @default.
- W2090201519 creator A5015636922 @default.
- W2090201519 creator A5016928431 @default.
- W2090201519 creator A5025173068 @default.
- W2090201519 creator A5044880204 @default.
- W2090201519 creator A5045420710 @default.
- W2090201519 creator A5059852221 @default.
- W2090201519 creator A5081437997 @default.
- W2090201519 date "2009-01-01" @default.
- W2090201519 modified "2023-10-18" @default.
- W2090201519 title "Metabolism of the colonic mucosa in patients with inflammatory bowel diseases: an in vitro proton magnetic resonance spectroscopy study" @default.
- W2090201519 cites W1612925887 @default.
- W2090201519 cites W1827908956 @default.
- W2090201519 cites W1867482183 @default.
- W2090201519 cites W1910910895 @default.
- W2090201519 cites W1916751165 @default.
- W2090201519 cites W1964477932 @default.
- W2090201519 cites W1968633234 @default.
- W2090201519 cites W1971672202 @default.
- W2090201519 cites W1981193852 @default.
- W2090201519 cites W1994759031 @default.
- W2090201519 cites W1997822058 @default.
- W2090201519 cites W2000778831 @default.
- W2090201519 cites W2010184221 @default.
- W2090201519 cites W2010396903 @default.
- W2090201519 cites W2047114414 @default.
- W2090201519 cites W2063380767 @default.
- W2090201519 cites W2067478712 @default.
- W2090201519 cites W2094136835 @default.
- W2090201519 cites W2100438777 @default.
- W2090201519 cites W2101866959 @default.
- W2090201519 cites W2101895513 @default.
- W2090201519 cites W2112449462 @default.
- W2090201519 cites W2120516622 @default.
- W2090201519 cites W2125417527 @default.
- W2090201519 cites W2130382164 @default.
- W2090201519 cites W2137898985 @default.
- W2090201519 cites W2139232831 @default.
- W2090201519 cites W2145819863 @default.
- W2090201519 cites W2171789845 @default.
- W2090201519 cites W2188248802 @default.
- W2090201519 cites W2291116084 @default.
- W2090201519 cites W3149527659 @default.
- W2090201519 cites W4241611245 @default.
- W2090201519 doi "https://doi.org/10.1016/j.mri.2008.05.014" @default.
- W2090201519 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18599242" @default.
- W2090201519 hasPublicationYear "2009" @default.
- W2090201519 type Work @default.
- W2090201519 sameAs 2090201519 @default.
- W2090201519 citedByCount "82" @default.
- W2090201519 countsByYear W20902015192012 @default.
- W2090201519 countsByYear W20902015192013 @default.
- W2090201519 countsByYear W20902015192014 @default.
- W2090201519 countsByYear W20902015192015 @default.
- W2090201519 countsByYear W20902015192016 @default.
- W2090201519 countsByYear W20902015192017 @default.
- W2090201519 countsByYear W20902015192018 @default.
- W2090201519 countsByYear W20902015192019 @default.
- W2090201519 countsByYear W20902015192020 @default.
- W2090201519 countsByYear W20902015192021 @default.
- W2090201519 countsByYear W20902015192022 @default.
- W2090201519 countsByYear W20902015192023 @default.
- W2090201519 crossrefType "journal-article" @default.
- W2090201519 hasAuthorship W2090201519A5015636922 @default.
- W2090201519 hasAuthorship W2090201519A5016928431 @default.
- W2090201519 hasAuthorship W2090201519A5025173068 @default.
- W2090201519 hasAuthorship W2090201519A5044880204 @default.
- W2090201519 hasAuthorship W2090201519A5045420710 @default.
- W2090201519 hasAuthorship W2090201519A5059852221 @default.
- W2090201519 hasAuthorship W2090201519A5081437997 @default.
- W2090201519 hasConcept C126322002 @default.
- W2090201519 hasConcept C134018914 @default.
- W2090201519 hasConcept C185592680 @default.
- W2090201519 hasConcept C2777573094 @default.
- W2090201519 hasConcept C2778260677 @default.
- W2090201519 hasConcept C2779134260 @default.
- W2090201519 hasConcept C2779349466 @default.
- W2090201519 hasConcept C2780479503 @default.
- W2090201519 hasConcept C3019368612 @default.
- W2090201519 hasConcept C515207424 @default.
- W2090201519 hasConcept C55493867 @default.
- W2090201519 hasConcept C62231903 @default.
- W2090201519 hasConcept C71924100 @default.
- W2090201519 hasConceptScore W2090201519C126322002 @default.
- W2090201519 hasConceptScore W2090201519C134018914 @default.
- W2090201519 hasConceptScore W2090201519C185592680 @default.
- W2090201519 hasConceptScore W2090201519C2777573094 @default.
- W2090201519 hasConceptScore W2090201519C2778260677 @default.
- W2090201519 hasConceptScore W2090201519C2779134260 @default.
- W2090201519 hasConceptScore W2090201519C2779349466 @default.
- W2090201519 hasConceptScore W2090201519C2780479503 @default.
- W2090201519 hasConceptScore W2090201519C3019368612 @default.
- W2090201519 hasConceptScore W2090201519C515207424 @default.
- W2090201519 hasConceptScore W2090201519C55493867 @default.
- W2090201519 hasConceptScore W2090201519C62231903 @default.
- W2090201519 hasConceptScore W2090201519C71924100 @default.
- W2090201519 hasIssue "1" @default.