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- W2090207161 abstract "Summary A double blind controlled trial was carried out in patients with pulmonary tuberculosis to determine the extent of tolerance to 2-ethylisothionicotinamide (‘1314’) when given in a dose of 0·5, 0·75 and 1·0 g. daily. At these dosage levels nausea was a common complaint in the 40 patients studied, though vomiting was infrequent. Complete absence of symptoms of intolerance was noted most often with the 0·5. dose of ‘1314’ and interruptions of treatment occurred more frequently with the larger doses of ‘1314’. Apart from the effect on the alimentary tract, no other important symptoms were noted. The development of significant drug intolerance to ‘1314’, when used in the treatment of patients with tuberculosis, is unfortunate as this may limit its usefulness particularly in the home treatment of tuberculosis. The optimum dose of this drug in tuberculosis is as yet unknown." @default.
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- W2090207161 date "1959-12-01" @default.
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- W2090207161 title "2-Ethylisothionicotinamide (‘1314’) in pulmonary tuberculosis: A controlled trial of drug tolerance" @default.
- W2090207161 cites W1984889748 @default.
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- W2090207161 doi "https://doi.org/10.1016/s0041-3879(59)80101-x" @default.
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