FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090216017> ?p ?o ?g. }

• W2090216017 abstract "In addition to lowering LDL-C, emerging data suggests that phytosterols (PS) may reduce blood triglycerides (TG), however, the underlying mechanisms are not known. We examined the TG-lowering mechanisms of dietary PS in Syrian golden hamsters randomly assigned to a high fat (HF) diet or the HF diet supplemented with PS (2%) for 6 weeks (n = 12/group). An additional subset of animals (n = 12) was provided the HF diet supplemented with ezetimibe (EZ, 0.002%) as a positive control as it is a cholesterol-lowering agent with known TG-lowering properties. In confirmation of diet formulation and compound delivery, both the PS and EZ treatments lowered (p < 0.05) intestinal cholesterol absorption (24 and 31%, respectively), blood non-HDL cholesterol (61 and 66%, respectively), and hepatic cholesterol (45 and 55%, respectively) compared with the HF-fed animals. Blood TG concentrations were lower (p < 0.05) in the PS (49%) and EZ (68%)-treated animals compared with the HF group. The TG-lowering response in the PS-supplemented group was associated with reduced (p < 0.05) intestinal SREBP1c mRNA (0.45 fold of HF), hepatic PPARα mRNA (0.73 fold of HF), hepatic FAS protein abundance (0.68 fold of HD), and de novo lipogenesis (44%) compared with the HF group. Similarly, lipogenesis was lower in the EZ-treated animals, albeit through a reduction in the hepatic protein abundance of ACC (0.47 fold of HF). Study results suggest that dietary PS are protective against diet-induced hypertriglyceridemia, likely through multiple mechanisms that involve modulation of intestinal fatty acid metabolism and a reduction in hepatic lipogenesis." @default.
• W2090216017 created "2016-06-24" @default.
• W2090216017 creator A5013333375 @default.
• W2090216017 creator A5029496040 @default.
• W2090216017 creator A5040300280 @default.
• W2090216017 creator A5044982105 @default.
• W2090216017 creator A5086106718 @default.
• W2090216017 creator A5091038506 @default.
• W2090216017 date "2014-01-06" @default.
• W2090216017 modified "2023-10-18" @default.
• W2090216017 title "Phytosterols protect against diet-induced hypertriglyceridemia in Syrian golden hamsters" @default.
• W2090216017 cites W1970142406 @default.
• W2090216017 cites W1984867757 @default.
• W2090216017 cites W2008879022 @default.
• W2090216017 cites W2013312937 @default.
• W2090216017 cites W2024851295 @default.
• W2090216017 cites W2029158612 @default.
• W2090216017 cites W2036747551 @default.
• W2090216017 cites W2042673262 @default.
• W2090216017 cites W2045183285 @default.
• W2090216017 cites W2048012004 @default.
• W2090216017 cites W2048222715 @default.
• W2090216017 cites W2049092532 @default.
• W2090216017 cites W2053631920 @default.
• W2090216017 cites W2055411353 @default.
• W2090216017 cites W2059148293 @default.
• W2090216017 cites W2061711675 @default.
• W2090216017 cites W2062131758 @default.
• W2090216017 cites W2062967728 @default.
• W2090216017 cites W2069307807 @default.
• W2090216017 cites W2069654229 @default.
• W2090216017 cites W2070918061 @default.
• W2090216017 cites W2092164199 @default.
• W2090216017 cites W2092176115 @default.
• W2090216017 cites W2093260782 @default.
• W2090216017 cites W2093616220 @default.
• W2090216017 cites W2101380733 @default.
• W2090216017 cites W2105337764 @default.
• W2090216017 cites W2106554416 @default.
• W2090216017 cites W2106620061 @default.
• W2090216017 cites W2107004670 @default.
• W2090216017 cites W2110442637 @default.
• W2090216017 cites W2111372703 @default.
• W2090216017 cites W2118316881 @default.
• W2090216017 cites W2136716194 @default.
• W2090216017 cites W2136823038 @default.
• W2090216017 cites W2137009721 @default.
• W2090216017 cites W2146955908 @default.
• W2090216017 cites W2149017724 @default.
• W2090216017 cites W2152652033 @default.
• W2090216017 cites W2162545188 @default.
• W2090216017 cites W2614570754 @default.
• W2090216017 doi "https://doi.org/10.1186/1476-511x-13-5" @default.
• W2090216017 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3896966" @default.
• W2090216017 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24393244" @default.
• W2090216017 hasPublicationYear "2014" @default.
• W2090216017 type Work @default.
• W2090216017 sameAs 2090216017 @default.
• W2090216017 citedByCount "26" @default.
• W2090216017 countsByYear W20902160172014 @default.
• W2090216017 countsByYear W20902160172015 @default.
• W2090216017 countsByYear W20902160172016 @default.
• W2090216017 countsByYear W20902160172017 @default.
• W2090216017 countsByYear W20902160172018 @default.
• W2090216017 countsByYear W20902160172019 @default.
• W2090216017 countsByYear W20902160172020 @default.
• W2090216017 countsByYear W20902160172021 @default.
• W2090216017 countsByYear W20902160172022 @default.
• W2090216017 countsByYear W20902160172023 @default.
• W2090216017 crossrefType "journal-article" @default.
• W2090216017 hasAuthorship W2090216017A5013333375 @default.
• W2090216017 hasAuthorship W2090216017A5029496040 @default.
• W2090216017 hasAuthorship W2090216017A5040300280 @default.
• W2090216017 hasAuthorship W2090216017A5044982105 @default.
• W2090216017 hasAuthorship W2090216017A5086106718 @default.
• W2090216017 hasAuthorship W2090216017A5091038506 @default.
• W2090216017 hasBestOaLocation W20902160171 @default.
• W2090216017 hasConcept C126322002 @default.
• W2090216017 hasConcept C134018914 @default.
• W2090216017 hasConcept C141359234 @default.
• W2090216017 hasConcept C185592680 @default.
• W2090216017 hasConcept C22894154 @default.
• W2090216017 hasConcept C2776919658 @default.
• W2090216017 hasConcept C2778163477 @default.
• W2090216017 hasConcept C2778913445 @default.
• W2090216017 hasConcept C382228 @default.
• W2090216017 hasConcept C62231903 @default.
• W2090216017 hasConcept C71924100 @default.
• W2090216017 hasConcept C86803240 @default.
• W2090216017 hasConceptScore W2090216017C126322002 @default.
• W2090216017 hasConceptScore W2090216017C134018914 @default.
• W2090216017 hasConceptScore W2090216017C141359234 @default.
• W2090216017 hasConceptScore W2090216017C185592680 @default.
• W2090216017 hasConceptScore W2090216017C22894154 @default.
• W2090216017 hasConceptScore W2090216017C2776919658 @default.
• W2090216017 hasConceptScore W2090216017C2778163477 @default.
• W2090216017 hasConceptScore W2090216017C2778913445 @default.
• W2090216017 hasConceptScore W2090216017C382228 @default.
• W2090216017 hasConceptScore W2090216017C62231903 @default.
• W2090216017 hasConceptScore W2090216017C71924100 @default.

• next