FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090216336> ?p ?o ?g. }

• W2090216336 endingPage "387" @default.
• W2090216336 startingPage "383" @default.
• W2090216336 abstract "Autoimmunity directed against antigens of immune privileged sites, which are hidden from the immune system by blood-organ-barriers, is difficult to explain: it would require already activated cells to enter the tissue where the respective autoantigens are sequestered. Autoimmune uveitis, a sight-threatening inflammatory disease of the eye, is such an example. To induce disease autoreactive T cells must have been activated outside the eye to pass the blood-retina-barrier and then crossreact with retinal autoantigen. We have described two environmental peptides mimicking a highly pathogenic epitope from retinal S-antigen. One mimicry antigen is from rotavirus, a common pathogen causing gastroenteritis, the other from bovine milk alpha s2casein, a frequent nutritional protein ought to induce oral tolerance. Lewis rats develop uveitis after immunization with both mimicry peptides and casein protein. However, these mimicry antigens failed to induce oral tolerance for protection from uveitis, suspecting that they rather induce immunity than tolerance. Humoral and cellular immune responses to these antigens are enhanced and more frequent in patients with uveitis compared to healthy individuals. Our findings suggest that multiple environmental antigens mimic autoantigens and might cause autoimmune diseases by eliciting defensive immune responses, however, they are not necessarily useful for therapeutic tolerance induction." @default.
• W2090216336 created "2016-06-24" @default.
• W2090216336 creator A5006518596 @default.
• W2090216336 creator A5077859270 @default.
• W2090216336 date "2004-07-01" @default.
• W2090216336 modified "2023-10-16" @default.
• W2090216336 title "Autoimmune uveitis and antigenic mimicry of environmental antigens" @default.
• W2090216336 cites W1520928619 @default.
• W2090216336 cites W1582619226 @default.
• W2090216336 cites W1956771404 @default.
• W2090216336 cites W1967174552 @default.
• W2090216336 cites W1968230095 @default.
• W2090216336 cites W1973813421 @default.
• W2090216336 cites W1985864341 @default.
• W2090216336 cites W1986216579 @default.
• W2090216336 cites W2000212755 @default.
• W2090216336 cites W2013795411 @default.
• W2090216336 cites W2015875235 @default.
• W2090216336 cites W2018027744 @default.
• W2090216336 cites W2025445086 @default.
• W2090216336 cites W2034242624 @default.
• W2090216336 cites W2050014902 @default.
• W2090216336 cites W2081366539 @default.
• W2090216336 cites W2122323666 @default.
• W2090216336 cites W2125582444 @default.
• W2090216336 cites W2126297588 @default.
• W2090216336 cites W2133969311 @default.
• W2090216336 cites W2153719403 @default.
• W2090216336 cites W2322403437 @default.
• W2090216336 cites W2395634957 @default.
• W2090216336 cites W2535672492 @default.
• W2090216336 doi "https://doi.org/10.1016/j.autrev.2004.01.002" @default.
• W2090216336 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15288005" @default.
• W2090216336 hasPublicationYear "2004" @default.
• W2090216336 type Work @default.
• W2090216336 sameAs 2090216336 @default.
• W2090216336 citedByCount "47" @default.
• W2090216336 countsByYear W20902163362012 @default.
• W2090216336 countsByYear W20902163362013 @default.
• W2090216336 countsByYear W20902163362014 @default.
• W2090216336 countsByYear W20902163362015 @default.
• W2090216336 countsByYear W20902163362016 @default.
• W2090216336 countsByYear W20902163362017 @default.
• W2090216336 countsByYear W20902163362018 @default.
• W2090216336 countsByYear W20902163362019 @default.
• W2090216336 countsByYear W20902163362020 @default.
• W2090216336 countsByYear W20902163362021 @default.
• W2090216336 countsByYear W20902163362022 @default.
• W2090216336 countsByYear W20902163362023 @default.
• W2090216336 crossrefType "journal-article" @default.
• W2090216336 hasAuthorship W2090216336A5006518596 @default.
• W2090216336 hasAuthorship W2090216336A5077859270 @default.
• W2090216336 hasConcept C147483822 @default.
• W2090216336 hasConcept C159654299 @default.
• W2090216336 hasConcept C163764329 @default.
• W2090216336 hasConcept C18903297 @default.
• W2090216336 hasConcept C195616568 @default.
• W2090216336 hasConcept C203014093 @default.
• W2090216336 hasConcept C2776194053 @default.
• W2090216336 hasConcept C2777119779 @default.
• W2090216336 hasConcept C2777702733 @default.
• W2090216336 hasConcept C2779075594 @default.
• W2090216336 hasConcept C2780130043 @default.
• W2090216336 hasConcept C7863114 @default.
• W2090216336 hasConcept C86803240 @default.
• W2090216336 hasConcept C8891405 @default.
• W2090216336 hasConceptScore W2090216336C147483822 @default.
• W2090216336 hasConceptScore W2090216336C159654299 @default.
• W2090216336 hasConceptScore W2090216336C163764329 @default.
• W2090216336 hasConceptScore W2090216336C18903297 @default.
• W2090216336 hasConceptScore W2090216336C195616568 @default.
• W2090216336 hasConceptScore W2090216336C203014093 @default.
• W2090216336 hasConceptScore W2090216336C2776194053 @default.
• W2090216336 hasConceptScore W2090216336C2777119779 @default.
• W2090216336 hasConceptScore W2090216336C2777702733 @default.
• W2090216336 hasConceptScore W2090216336C2779075594 @default.
• W2090216336 hasConceptScore W2090216336C2780130043 @default.
• W2090216336 hasConceptScore W2090216336C7863114 @default.
• W2090216336 hasConceptScore W2090216336C86803240 @default.
• W2090216336 hasConceptScore W2090216336C8891405 @default.
• W2090216336 hasIssue "5" @default.
• W2090216336 hasLocation W20902163361 @default.
• W2090216336 hasLocation W20902163362 @default.
• W2090216336 hasOpenAccess W2090216336 @default.
• W2090216336 hasPrimaryLocation W20902163361 @default.
• W2090216336 hasRelatedWork W2035368461 @default.
• W2090216336 hasRelatedWork W2090216336 @default.
• W2090216336 hasRelatedWork W2094417381 @default.
• W2090216336 hasRelatedWork W2098138696 @default.
• W2090216336 hasRelatedWork W2161246929 @default.
• W2090216336 hasRelatedWork W2326896496 @default.
• W2090216336 hasRelatedWork W2626874754 @default.
• W2090216336 hasRelatedWork W2766966584 @default.
• W2090216336 hasRelatedWork W2907025905 @default.
• W2090216336 hasRelatedWork W3118560759 @default.
• W2090216336 hasVolume "3" @default.
• W2090216336 isParatext "false" @default.
• W2090216336 isRetracted "false" @default.

• next