Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090231610> ?p ?o ?g. }
- W2090231610 endingPage "341" @default.
- W2090231610 startingPage "335" @default.
- W2090231610 abstract "The development of acute pancreatitis is characterized by profound changes in pancreatic microcirculation. Using in vivo microscopy with fluorescent-labeled erythrocytes as tracers we studied changes in pancreatic microcirculation in an improved rat model of necrotizing pancreatitis (NP) in comparison to edematous pancreatitis (EP) and healthy controls.Twenty-one male Wistar rats had their pancreatae exteriorized in a temperature-controlled immersion chamber followed by intravenous administration of fluorescent-labeled autologous erythrocytes. EP was induced by intraductal saline and intravenous caerulein (5 microg/kg/h) for 6 h (n = 7) and NP by controlled intraductal infusion of glycodeoxycholic acid (10 mmol/L) followed by intravenous caerulein (n = 7). Control animals received intraductal and intravenous saline (n = 7). The determination of pancreatic microcirculation was performed before as well as 1, 3, and 6 h after intraductal infusion by correlating the number of passing labeled erythrocytes/capillary/min with their concentration per microliter of arterial blood.Pancreatic capillary flow in control animals remained constant over the 6-h observation period. Pancreatic capillary flow in the EP group rapidly increased to 188% of baseline after 3 h and remained significantly elevated throughout the experiments (P = 0.0001). In contrast, pancreatic capillary flow decreased significantly in the group suffering NP with values 46.7% of baseline after 6 h (P = 0.0001). Complete capillary stasis developed in 38% of investigated capillaries in the NP group compared to 0-1% in both other groups (P = 0.0001).Pancreatic microcirculation in mild edematous pancreatitis is significantly increased while the evolution of necrotizing pancreatitis in the model studied herein is characterized by a dramatic reduction in pancreatic capillary flow in conjunction with areas of capillary stasis. These results underline the pathophysiologic relevance of the model and of therapeutic measures aimed at an improvement of pancreatic microcirculation in clinical necrotizing pancreatitis." @default.
- W2090231610 created "2016-06-24" @default.
- W2090231610 creator A5005796927 @default.
- W2090231610 creator A5006706914 @default.
- W2090231610 creator A5018615422 @default.
- W2090231610 creator A5058360849 @default.
- W2090231610 creator A5067125554 @default.
- W2090231610 creator A5086114227 @default.
- W2090231610 date "2002-08-01" @default.
- W2090231610 modified "2023-10-16" @default.
- W2090231610 title "Pancreatic Capillary Blood Flow in an Improved Model of Necrotizing Pancreatitis in the Rat" @default.
- W2090231610 cites W1554265226 @default.
- W2090231610 cites W1562224331 @default.
- W2090231610 cites W1877216463 @default.
- W2090231610 cites W193076644 @default.
- W2090231610 cites W1969361782 @default.
- W2090231610 cites W1976156639 @default.
- W2090231610 cites W1977280111 @default.
- W2090231610 cites W1978111868 @default.
- W2090231610 cites W1984261925 @default.
- W2090231610 cites W1998302005 @default.
- W2090231610 cites W2002582583 @default.
- W2090231610 cites W2003410485 @default.
- W2090231610 cites W2005149171 @default.
- W2090231610 cites W2009364795 @default.
- W2090231610 cites W2027585495 @default.
- W2090231610 cites W2043945385 @default.
- W2090231610 cites W2047233148 @default.
- W2090231610 cites W2059146195 @default.
- W2090231610 cites W2059450361 @default.
- W2090231610 cites W2059670189 @default.
- W2090231610 cites W2059930904 @default.
- W2090231610 cites W2059996560 @default.
- W2090231610 cites W2063023219 @default.
- W2090231610 cites W2063513460 @default.
- W2090231610 cites W2066953347 @default.
- W2090231610 cites W2068125708 @default.
- W2090231610 cites W2068519537 @default.
- W2090231610 cites W2068728222 @default.
- W2090231610 cites W2072736459 @default.
- W2090231610 cites W2075715557 @default.
- W2090231610 cites W2077105259 @default.
- W2090231610 cites W2082341715 @default.
- W2090231610 cites W2086481431 @default.
- W2090231610 cites W2087197999 @default.
- W2090231610 cites W2088332257 @default.
- W2090231610 cites W2090470064 @default.
- W2090231610 cites W2094929360 @default.
- W2090231610 cites W2131124156 @default.
- W2090231610 cites W2148278970 @default.
- W2090231610 cites W2149744820 @default.
- W2090231610 cites W2150200775 @default.
- W2090231610 cites W2150905243 @default.
- W2090231610 cites W2165889447 @default.
- W2090231610 cites W2170553582 @default.
- W2090231610 cites W2409313268 @default.
- W2090231610 cites W41320883 @default.
- W2090231610 doi "https://doi.org/10.1006/jsre.2002.6464" @default.
- W2090231610 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12175989" @default.
- W2090231610 hasPublicationYear "2002" @default.
- W2090231610 type Work @default.
- W2090231610 sameAs 2090231610 @default.
- W2090231610 citedByCount "28" @default.
- W2090231610 countsByYear W20902316102013 @default.
- W2090231610 countsByYear W20902316102014 @default.
- W2090231610 countsByYear W20902316102017 @default.
- W2090231610 countsByYear W20902316102018 @default.
- W2090231610 countsByYear W20902316102019 @default.
- W2090231610 countsByYear W20902316102022 @default.
- W2090231610 crossrefType "journal-article" @default.
- W2090231610 hasAuthorship W2090231610A5005796927 @default.
- W2090231610 hasAuthorship W2090231610A5006706914 @default.
- W2090231610 hasAuthorship W2090231610A5018615422 @default.
- W2090231610 hasAuthorship W2090231610A5058360849 @default.
- W2090231610 hasAuthorship W2090231610A5067125554 @default.
- W2090231610 hasAuthorship W2090231610A5086114227 @default.
- W2090231610 hasConcept C126322002 @default.
- W2090231610 hasConcept C12722491 @default.
- W2090231610 hasConcept C134018914 @default.
- W2090231610 hasConcept C142724271 @default.
- W2090231610 hasConcept C146957229 @default.
- W2090231610 hasConcept C150903083 @default.
- W2090231610 hasConcept C158846371 @default.
- W2090231610 hasConcept C207001950 @default.
- W2090231610 hasConcept C2775967933 @default.
- W2090231610 hasConcept C2776670229 @default.
- W2090231610 hasConcept C2776737053 @default.
- W2090231610 hasConcept C2777397205 @default.
- W2090231610 hasConcept C2778764654 @default.
- W2090231610 hasConcept C2910062394 @default.
- W2090231610 hasConcept C71924100 @default.
- W2090231610 hasConcept C86803240 @default.
- W2090231610 hasConcept C90924648 @default.
- W2090231610 hasConceptScore W2090231610C126322002 @default.
- W2090231610 hasConceptScore W2090231610C12722491 @default.
- W2090231610 hasConceptScore W2090231610C134018914 @default.
- W2090231610 hasConceptScore W2090231610C142724271 @default.
- W2090231610 hasConceptScore W2090231610C146957229 @default.