FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090236139> ?p ?o ?g. }

• W2090236139 endingPage "293" @default.
• W2090236139 startingPage "285" @default.
• W2090236139 abstract "Much of the lethality of malignant neoplasms is attributable directly to their ability to develop secondary growths in organs at a distance from the primary tumor mass, whereas few patients die from their primary neoplasm. Little is known about the molecular mechanism of tumor metastasis, however, which is controlled by a variety of positive and negative factors. In the search for metastasis suppressor genes, we have used the microcell-mediated chromosome transfer method and a rat prostate tumor model in SCID mice. When human chromosome 2 was introduced into the highly metastatic rat prostatic tumor cell, AT6.1, the metastatic ability of this cell was significantly (>99%) decreased in animals. An STS-based PCR analysis for 8 hybrid clones indicates that the suppressor activity is located in the p25-22 region of the chromosome. Furthermore, the AT6.1 cell with human chromosome 2 showed a reduced ability to invade Matrigel, suggesting that the suppressor activity is involved in the step of tumor invasion during the progression of prostate cancer. We have also examined the status of the suppressor region on chromosome 2 in human prostate cancer specimens and found that this region was often lost in high-grade tumors. These results suggest that the putative suppressor gene on chromosome 2 is functionally involved in the progression of human prostate cancer. Genes Chromosomes Cancer 28:285-293, 2000." @default.
• W2090236139 created "2016-06-24" @default.
• W2090236139 creator A5004550586 @default.
• W2090236139 creator A5007660652 @default.
• W2090236139 creator A5015396895 @default.
• W2090236139 creator A5020096970 @default.
• W2090236139 creator A5038352173 @default.
• W2090236139 creator A5039382964 @default.
• W2090236139 creator A5064069499 @default.
• W2090236139 creator A5078542282 @default.
• W2090236139 creator A5079501256 @default.
• W2090236139 creator A5084103384 @default.
• W2090236139 creator A5085313241 @default.
• W2090236139 creator A5088426511 @default.
• W2090236139 date "2000-01-01" @default.
• W2090236139 modified "2023-10-16" @default.
• W2090236139 title "Localization of a novel tumor metastasis suppressor region on the short arm of human chromosome 2" @default.
• W2090236139 cites W1965751129 @default.
• W2090236139 cites W1966189220 @default.
• W2090236139 cites W1993704913 @default.
• W2090236139 cites W1994128692 @default.
• W2090236139 cites W1996532680 @default.
• W2090236139 cites W2003125583 @default.
• W2090236139 cites W2017767253 @default.
• W2090236139 cites W2039844465 @default.
• W2090236139 cites W2041648111 @default.
• W2090236139 cites W2056626164 @default.
• W2090236139 cites W2064831203 @default.
• W2090236139 cites W2068776651 @default.
• W2090236139 cites W2077629355 @default.
• W2090236139 cites W2101363963 @default.
• W2090236139 cites W2107124227 @default.
• W2090236139 cites W2137184054 @default.
• W2090236139 cites W2319499179 @default.
• W2090236139 cites W2330593753 @default.
• W2090236139 doi "https://doi.org/10.1002/1098-2264(200007)28:3<285::aid-gcc6>3.0.co;2-o" @default.
• W2090236139 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10862034" @default.
• W2090236139 hasPublicationYear "2000" @default.
• W2090236139 type Work @default.
• W2090236139 sameAs 2090236139 @default.
• W2090236139 citedByCount "15" @default.
• W2090236139 crossrefType "journal-article" @default.
• W2090236139 hasAuthorship W2090236139A5004550586 @default.
• W2090236139 hasAuthorship W2090236139A5007660652 @default.
• W2090236139 hasAuthorship W2090236139A5015396895 @default.
• W2090236139 hasAuthorship W2090236139A5020096970 @default.
• W2090236139 hasAuthorship W2090236139A5038352173 @default.
• W2090236139 hasAuthorship W2090236139A5039382964 @default.
• W2090236139 hasAuthorship W2090236139A5064069499 @default.
• W2090236139 hasAuthorship W2090236139A5078542282 @default.
• W2090236139 hasAuthorship W2090236139A5079501256 @default.
• W2090236139 hasAuthorship W2090236139A5084103384 @default.
• W2090236139 hasAuthorship W2090236139A5085313241 @default.
• W2090236139 hasAuthorship W2090236139A5088426511 @default.
• W2090236139 hasConcept C104317684 @default.
• W2090236139 hasConcept C121608353 @default.
• W2090236139 hasConcept C142724271 @default.
• W2090236139 hasConcept C179185449 @default.
• W2090236139 hasConcept C205003668 @default.
• W2090236139 hasConcept C2778025950 @default.
• W2090236139 hasConcept C2778264664 @default.
• W2090236139 hasConcept C2779013556 @default.
• W2090236139 hasConcept C2779256057 @default.
• W2090236139 hasConcept C2780192828 @default.
• W2090236139 hasConcept C2780283643 @default.
• W2090236139 hasConcept C2909960190 @default.
• W2090236139 hasConcept C30481170 @default.
• W2090236139 hasConcept C502942594 @default.
• W2090236139 hasConcept C54355233 @default.
• W2090236139 hasConcept C555283112 @default.
• W2090236139 hasConcept C71924100 @default.
• W2090236139 hasConcept C86803240 @default.
• W2090236139 hasConcept C87874733 @default.
• W2090236139 hasConceptScore W2090236139C104317684 @default.
• W2090236139 hasConceptScore W2090236139C121608353 @default.
• W2090236139 hasConceptScore W2090236139C142724271 @default.
• W2090236139 hasConceptScore W2090236139C179185449 @default.
• W2090236139 hasConceptScore W2090236139C205003668 @default.
• W2090236139 hasConceptScore W2090236139C2778025950 @default.
• W2090236139 hasConceptScore W2090236139C2778264664 @default.
• W2090236139 hasConceptScore W2090236139C2779013556 @default.
• W2090236139 hasConceptScore W2090236139C2779256057 @default.
• W2090236139 hasConceptScore W2090236139C2780192828 @default.
• W2090236139 hasConceptScore W2090236139C2780283643 @default.
• W2090236139 hasConceptScore W2090236139C2909960190 @default.
• W2090236139 hasConceptScore W2090236139C30481170 @default.
• W2090236139 hasConceptScore W2090236139C502942594 @default.
• W2090236139 hasConceptScore W2090236139C54355233 @default.
• W2090236139 hasConceptScore W2090236139C555283112 @default.
• W2090236139 hasConceptScore W2090236139C71924100 @default.
• W2090236139 hasConceptScore W2090236139C86803240 @default.
• W2090236139 hasConceptScore W2090236139C87874733 @default.
• W2090236139 hasIssue "3" @default.
• W2090236139 hasLocation W20902361391 @default.
• W2090236139 hasLocation W20902361392 @default.
• W2090236139 hasOpenAccess W2090236139 @default.
• W2090236139 hasPrimaryLocation W20902361391 @default.
• W2090236139 hasRelatedWork W122355242 @default.

• next