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- W2090250363 abstract "Controlled-release carbidopa/levodopa 50/200 (SINEMET CR) and standard carbidopa/levodopa (SINEMET 25/100) were compared in a double-blind, six-month, crossover study involving 21 patients with chronic Parkinson's disease and motor response fluctuations. Daily dosage frequency was significantly reduced with SINEMET CR compared with SINEMET 25/100, while the daily amount of levodopa required with SINEMET CR was significantly greater. No significant differences in disability ratings, motor response fluctuations, or safety were detected during double-blind conditions. In the open-label, dose-finding phase of the study, SINEMET CR was superior to standard SINEMET 25/100 in patient ratings of percent on time (good motor function), clinical assessments of motor function, and activities of daily living. This finding resulted from a depreciation of the value of the old drug rather than an overestimation of the value of the experimental drug. This double-blind study also suggested that elderly male patients with Parkinson's disease derived the greatest benefit from SINEMET CR." @default.
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- W2090250363 date "1988-08-01" @default.
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- W2090250363 title "Treatment of Chronic Parkinson's Disease With Controlled-Release Carbidopa/Levodopa" @default.
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- W2090250363 doi "https://doi.org/10.1001/archneur.1988.00520320047014" @default.
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