FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090252012> ?p ?o ?g. }

• W2090252012 endingPage "74" @default.
• W2090252012 startingPage "63" @default.
• W2090252012 abstract "G-protein coupled receptors catalyze nucleotide exchange on G proteins, which results in subunit dissociation and effector activation. In the recent β 2 AR-G s structure, portions of Switch I and II of Gα are not fully elucidated. We paired fluorescence studies of receptor-Gα i interactions with the β 2 AR-G s and other G i structures to investigate changes in Switch I and II during receptor activation and GTP binding. The β2/β3 loop containing Leu194 of Gα i is located between Switches I and II, in close proximity to IC2 of the receptor and the C-terminus of Gα, thus providing an allosteric connection between these Switches and receptor activation. We compared the environment of residues in myristoylated Gα i proteins in the heterotrimer to that upon receptor activation and subsequent GTP binding. Upon receptor activation, residues in both Switch regions are less solvent-exposed, as compared to the heterotrimer. Upon GTPγS binding, the environment of several residues in Switch I resemble the receptor-bound state, while Switch II residues display effects on their environment which are consistent with their role in GTP binding and Gβγ dissociation. The ability to merge available crystal structures with solution studies is a powerful tool to gain insight into conformational changes associated with receptor-mediated G i protein activation." @default.
• W2090252012 created "2016-06-24" @default.
• W2090252012 creator A5023618339 @default.
• W2090252012 creator A5044374954 @default.
• W2090252012 creator A5068550892 @default.
• W2090252012 creator A5080797625 @default.
• W2090252012 date "2013-10-01" @default.
• W2090252012 modified "2023-10-12" @default.
• W2090252012 title "Linking receptor activation to changes in Sw I and II of Gα proteins" @default.
• W2090252012 cites W1482828226 @default.
• W2090252012 cites W1485119817 @default.
• W2090252012 cites W1495233639 @default.
• W2090252012 cites W1499695147 @default.
• W2090252012 cites W1523056580 @default.
• W2090252012 cites W1542297269 @default.
• W2090252012 cites W1894296128 @default.
• W2090252012 cites W1942777601 @default.
• W2090252012 cites W1965275686 @default.
• W2090252012 cites W1967058469 @default.
• W2090252012 cites W1969451894 @default.
• W2090252012 cites W1969475556 @default.
• W2090252012 cites W1974770940 @default.
• W2090252012 cites W1978501212 @default.
• W2090252012 cites W1978798664 @default.
• W2090252012 cites W1980058356 @default.
• W2090252012 cites W1984702729 @default.
• W2090252012 cites W1989971979 @default.
• W2090252012 cites W1994864252 @default.
• W2090252012 cites W1994953274 @default.
• W2090252012 cites W1995372228 @default.
• W2090252012 cites W1997161001 @default.
• W2090252012 cites W1997180803 @default.
• W2090252012 cites W2001711011 @default.
• W2090252012 cites W2004125744 @default.
• W2090252012 cites W2009192117 @default.
• W2090252012 cites W2010544588 @default.
• W2090252012 cites W2011346959 @default.
• W2090252012 cites W2015176049 @default.
• W2090252012 cites W2015939094 @default.
• W2090252012 cites W2016441306 @default.
• W2090252012 cites W2020086703 @default.
• W2090252012 cites W2022754746 @default.
• W2090252012 cites W2023038974 @default.
• W2090252012 cites W2024601283 @default.
• W2090252012 cites W2024850327 @default.
• W2090252012 cites W2025634059 @default.
• W2090252012 cites W2026633461 @default.
• W2090252012 cites W2030185192 @default.
• W2090252012 cites W2039493283 @default.
• W2090252012 cites W2041473308 @default.
• W2090252012 cites W2056261267 @default.
• W2090252012 cites W2059373278 @default.
• W2090252012 cites W2064118841 @default.
• W2090252012 cites W2064664612 @default.
• W2090252012 cites W2074292010 @default.
• W2090252012 cites W2078497357 @default.
• W2090252012 cites W2082192115 @default.
• W2090252012 cites W2093626313 @default.
• W2090252012 cites W2114460420 @default.
• W2090252012 cites W2116398954 @default.
• W2090252012 cites W2123061927 @default.
• W2090252012 cites W2124961362 @default.
• W2090252012 cites W2131639373 @default.
• W2090252012 cites W2132629607 @default.
• W2090252012 cites W2133251633 @default.
• W2090252012 cites W2136906322 @default.
• W2090252012 cites W2137827496 @default.
• W2090252012 cites W2140686653 @default.
• W2090252012 cites W2143682175 @default.
• W2090252012 cites W2145711394 @default.
• W2090252012 cites W2146262467 @default.
• W2090252012 cites W2165888364 @default.
• W2090252012 cites W2167857702 @default.
• W2090252012 cites W2396482552 @default.
• W2090252012 cites W2413435377 @default.
• W2090252012 cites W255996521 @default.
• W2090252012 cites W50079648 @default.
• W2090252012 doi "https://doi.org/10.1016/j.jsb.2013.02.016" @default.
• W2090252012 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3726552" @default.
• W2090252012 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23466875" @default.
• W2090252012 hasPublicationYear "2013" @default.
• W2090252012 type Work @default.
• W2090252012 sameAs 2090252012 @default.
• W2090252012 citedByCount "8" @default.
• W2090252012 countsByYear W20902520122013 @default.
• W2090252012 countsByYear W20902520122014 @default.
• W2090252012 countsByYear W20902520122015 @default.
• W2090252012 countsByYear W20902520122016 @default.
• W2090252012 countsByYear W20902520122018 @default.
• W2090252012 crossrefType "journal-article" @default.
• W2090252012 hasAuthorship W2090252012A5023618339 @default.
• W2090252012 hasAuthorship W2090252012A5044374954 @default.
• W2090252012 hasAuthorship W2090252012A5068550892 @default.
• W2090252012 hasAuthorship W2090252012A5080797625 @default.
• W2090252012 hasBestOaLocation W20902520122 @default.
• W2090252012 hasConcept C118716 @default.
• W2090252012 hasConcept C12554922 @default.
• W2090252012 hasConcept C135285700 @default.

• next