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- W2090255262 abstract "The interaction of PAMPs with cells of the innate immune system shapes the adaptive host response. Here, we report that β-glucan, a major fungal PAMP purified from Candida albicans, stimulates human DCs to secrete a pro-Th17 cytokine pattern. Notably, β-glucan induces PGE2 production, which has been shown to play a pivotal role in Th17 cell expansion. Inhibition of PGE2 synthesis or blockade of PGE2 receptors EP2 and EP4 drastically reduces IL-23 production by β-glucan-activated DCs, suggesting that endogenous PGE2 amplifies IL-23 synthesis in response to the C. albicans PAMP. Moreover β-glucan promotes the expansion of Th17 cells, which is strongly decreased by EP2 and EP4 receptor blockade on DCs. Our results highlight a novel role for PGE2 in the regulation of innate and adaptive immune response triggered by recognition of a prominent, highly conserved fungal PAMP such as β-glucan." @default.
- W2090255262 created "2016-06-24" @default.
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- W2090255262 date "2010-08-31" @default.
- W2090255262 modified "2023-10-18" @default.
- W2090255262 title "Endogenous PGE2 promotes the induction of human Th17 responses by fungal β-glucan" @default.
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- W2090255262 doi "https://doi.org/10.1189/jlb.0310139" @default.
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