FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090264909> ?p ?o ?g. }

• W2090264909 endingPage "4765" @default.
• W2090264909 startingPage "4760" @default.
• W2090264909 abstract "We report here a cancer drug therapy use of a gene involved in Down's syndrome. Using bioinformatics approaches, we recently predicted Single Minded 2 gene (SIM2) from Down's syndrome critical region to be specific to certain solid tumors. Involvement of SIM2 in solid tumors has not previously been reported. Intrigued by a possible association between a Down's syndrome gene and solid tumors, we monitored SIM2 expression in solid tumors. Isoform-specific expression of SIM2 short-form (SIM2-s) was seen selectively in colon, prostate, and pancreatic carcinomas but not in breast, lung, or ovarian carcinomas nor in most normal tissues. In colon tumors, SIM2-s expression was seen in early stages. Antisense inhibition of SIM2-s expression in a colon cancer cell line caused inhibition of gene expression, growth inhibition, and apoptosis. The administration of the antisense, but not the control, oligonucleotides caused a pronounced inhibition of tumor growth in nude mice with no major toxicity. Our findings provide a strong rationale for the genes-to-drugs paradigm, establish SIM2-s as a molecular target for cancer therapeutics, and may further understanding of the cancer risk of Down's syndrome patients." @default.
• W2090264909 created "2016-06-24" @default.
• W2090264909 creator A5000386893 @default.
• W2090264909 creator A5063538202 @default.
• W2090264909 creator A5073540522 @default.
• W2090264909 date "2003-04-03" @default.
• W2090264909 modified "2023-09-30" @default.
• W2090264909 title "Identification of Down's syndrome critical locus gene <i>SIM2-s</i> as a drug therapy target for solid tumors" @default.
• W2090264909 cites W1498903889 @default.
• W2090264909 cites W1670899815 @default.
• W2090264909 cites W1946122945 @default.
• W2090264909 cites W1971494855 @default.
• W2090264909 cites W1974549513 @default.
• W2090264909 cites W1984965536 @default.
• W2090264909 cites W1990874048 @default.
• W2090264909 cites W1992682395 @default.
• W2090264909 cites W2017133589 @default.
• W2090264909 cites W2025646550 @default.
• W2090264909 cites W2039357027 @default.
• W2090264909 cites W2041149810 @default.
• W2090264909 cites W2045931107 @default.
• W2090264909 cites W2051859228 @default.
• W2090264909 cites W2061474690 @default.
• W2090264909 cites W2063751484 @default.
• W2090264909 cites W2074122556 @default.
• W2090264909 cites W2087684630 @default.
• W2090264909 cites W2096525273 @default.
• W2090264909 cites W2101778401 @default.
• W2090264909 cites W2107867483 @default.
• W2090264909 cites W2113658348 @default.
• W2090264909 cites W2122872071 @default.
• W2090264909 cites W2124259172 @default.
• W2090264909 cites W2141323846 @default.
• W2090264909 cites W2144882221 @default.
• W2090264909 cites W2146909058 @default.
• W2090264909 cites W2161967149 @default.
• W2090264909 cites W2162748174 @default.
• W2090264909 cites W2163176957 @default.
• W2090264909 cites W2163490748 @default.
• W2090264909 cites W2335221008 @default.
• W2090264909 cites W2404338653 @default.
• W2090264909 cites W2410096833 @default.
• W2090264909 cites W2417700906 @default.
• W2090264909 cites W2952519723 @default.
• W2090264909 cites W4211261801 @default.
• W2090264909 cites W4230903726 @default.
• W2090264909 cites W4237129117 @default.
• W2090264909 cites W4249877820 @default.
• W2090264909 cites W4301328756 @default.
• W2090264909 doi "https://doi.org/10.1073/pnas.0831000100" @default.
• W2090264909 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/153629" @default.
• W2090264909 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12676991" @default.
• W2090264909 hasPublicationYear "2003" @default.
• W2090264909 type Work @default.
• W2090264909 sameAs 2090264909 @default.
• W2090264909 citedByCount "46" @default.
• W2090264909 countsByYear W20902649092012 @default.
• W2090264909 countsByYear W20902649092013 @default.
• W2090264909 countsByYear W20902649092014 @default.
• W2090264909 countsByYear W20902649092015 @default.
• W2090264909 countsByYear W20902649092017 @default.
• W2090264909 countsByYear W20902649092018 @default.
• W2090264909 countsByYear W20902649092020 @default.
• W2090264909 countsByYear W20902649092021 @default.
• W2090264909 countsByYear W20902649092023 @default.
• W2090264909 crossrefType "journal-article" @default.
• W2090264909 hasAuthorship W2090264909A5000386893 @default.
• W2090264909 hasAuthorship W2090264909A5063538202 @default.
• W2090264909 hasAuthorship W2090264909A5073540522 @default.
• W2090264909 hasBestOaLocation W20902649092 @default.
• W2090264909 hasConcept C104317684 @default.
• W2090264909 hasConcept C111599444 @default.
• W2090264909 hasConcept C121608353 @default.
• W2090264909 hasConcept C126322002 @default.
• W2090264909 hasConcept C150194340 @default.
• W2090264909 hasConcept C2780427987 @default.
• W2090264909 hasConcept C502942594 @default.
• W2090264909 hasConcept C526805850 @default.
• W2090264909 hasConcept C53345823 @default.
• W2090264909 hasConcept C54355233 @default.
• W2090264909 hasConcept C71924100 @default.
• W2090264909 hasConcept C86803240 @default.
• W2090264909 hasConceptScore W2090264909C104317684 @default.
• W2090264909 hasConceptScore W2090264909C111599444 @default.
• W2090264909 hasConceptScore W2090264909C121608353 @default.
• W2090264909 hasConceptScore W2090264909C126322002 @default.
• W2090264909 hasConceptScore W2090264909C150194340 @default.
• W2090264909 hasConceptScore W2090264909C2780427987 @default.
• W2090264909 hasConceptScore W2090264909C502942594 @default.
• W2090264909 hasConceptScore W2090264909C526805850 @default.
• W2090264909 hasConceptScore W2090264909C53345823 @default.
• W2090264909 hasConceptScore W2090264909C54355233 @default.
• W2090264909 hasConceptScore W2090264909C71924100 @default.
• W2090264909 hasConceptScore W2090264909C86803240 @default.
• W2090264909 hasIssue "8" @default.
• W2090264909 hasLocation W20902649091 @default.
• W2090264909 hasLocation W20902649092 @default.
• W2090264909 hasLocation W20902649093 @default.

• next