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- W2090274013 endingPage "e10691" @default.
- W2090274013 startingPage "e10691" @default.
- W2090274013 abstract "Background Considerable evidence indicates that heparan sulfate is essential for the development of tissues consisting of branching ducts and tubules. However, there are few examples where specific sulfate residues regulate a specific stage in the formation of such tissues. Methodology/Principal Findings We examined the role of heparan sulfation in mammary gland branching morphogenesis, lactation and lobuloalveolar development by inactivation of heparan sulfate GlcNAc N-deacetylase/N-sulfotransferase genes (Ndst) in mammary epithelial cells using the Cre-loxP system. Ndst1 deficiency resulted in an overall reduction in glucosamine N-sulfation and decreased binding of FGF to mammary epithelial cells in vitro and in vivo. Mammary epithelia lacking Ndst1 underwent branching morphogenesis, filling the gland with ductal tissue by sexual maturity to the same extent as wildtype epithelia. However, lobuloalveolar expansion did not occur in Ndst1-deficient animals, resulting in insufficient milk production to nurture newly born pups. Lactational differentiation of isolated mammary epithelial cells occurred appropriately via stat5 activation, further supporting the notion that the lack of milk production was due to lack of expansion of the lobuloalveoli. Conclusions/Significance These findings demonstrate a selective, highly penetrant, cell autonomous effect of Ndst1-mediated sulfation on lobuloalveolar development." @default.
- W2090274013 created "2016-06-24" @default.
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- W2090274013 creator A5051393984 @default.
- W2090274013 creator A5059137254 @default.
- W2090274013 creator A5067976238 @default.
- W2090274013 date "2010-05-18" @default.
- W2090274013 modified "2023-10-16" @default.
- W2090274013 title "Loss of the Heparan Sulfate Sulfotransferase, Ndst1, in Mammary Epithelial Cells Selectively Blocks Lobuloalveolar Development in Mice" @default.
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- W2090274013 doi "https://doi.org/10.1371/journal.pone.0010691" @default.
- W2090274013 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2872662" @default.
- W2090274013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20502530" @default.
- W2090274013 hasPublicationYear "2010" @default.
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