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• W2090276684 abstract "Growth-associated protein 43(GAP-43) is closely associated with development, formation and plasticity of synapse, and nerve regeneration, and plays a key role in the new connection of conducting axon growth and axon formation. This study aimed to investigate the effect of GETO, a combination of herbal active components, on expression of GAP-43 in CA1 of hippocampus of Alzheimer's disease (AD) model rats induced by Aβ. AD model were prepared by Aβ-amyloid (Aβ1–42) agglomeration injection into hippocampus in rats. The brains of AD model rats were cut after intragastric administration of GETO 0.10g/Kg/d for a 4 weeks and frozen brain tissues were continuously sliced to 20 slides, one third of them were used in immunohistochemical stains with GAP-43 antibodies. A System of Iimage Ppro-plus was used to gain the number and OD density of positive neurons. The number of positive neurons stained by GAP-43 antibody in hippocampus CA1 in the GETO rats was 77.06±14.66, which was not only significantly higher than the 52.33±28.45 in the model rats (P<0.01), and significantly higher than the 51.26±22.44 in the Donepezil rats (P<0.01). The optics density of stained positive neuron in hippocampus CA1 of GAP-43 in the GERP rats was 75.44±5.29, which was significantly lower than the 92.77±7.37 in the model rats (P<0.01), but not significantly different from those (71.30±11.65) in the normal rats and those (73.09±5.18) in the Donepezil rats (P<0.05). This study suggests that GETO can increase expression of GAP-43 protein in hippocampus CA1 in the brain with AD model induced by Aβ 1–42 peptide. This may be a new evidence for GETO in promoting neuronal growth and improving synaptic plasticity of neurons in hippocampus CA1 in the brain with AD. This work was supported by The 973 Project (Grant No. 2003CB517104), The 111 Project (Grant No. B08006), The NSFC Project (Grant No. 30672693), and Chutian Scholars Project." @default.
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• W2090276684 date "2008-07-01" @default.
• W2090276684 modified "2023-09-25" @default.
• W2090276684 title "P2-360: Effect of GETO expression of growth-associated protein 43" @default.
• W2090276684 doi "https://doi.org/10.1016/j.jalz.2008.05.1438" @default.
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