FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090277946> ?p ?o ?g. }

• W2090277946 endingPage "1288" @default.
• W2090277946 startingPage "1280" @default.
• W2090277946 abstract "Mutation in the EGFP domain of LDL receptor-related protein 6 (LRP6 R611C ) is associated with hypercholesterolemia and early-onset atherosclerosis, but the mechanism by which it causes disease is not known. Cholesterol uptake was examined in cells from LRP6 +/− mice and LRP6 R611C mutation carriers. Splenic B cells of LRP6 +/− mice have significantly lower LRP6 expression and low-density lipoprotein (LDL) uptake than those of the wild-type littermates. Although similar levels of total LRP6 were found in lymphoblastoid cells (LCLs) of LRP6 R611C mutation carriers and those of the unaffected family member, LDL uptake was significantly lower in the mutant cells. Mutant and wild-type receptors show similar affinities for apolipoprotein B at neutral pH. LRP6 colocalized with LDL and was coimmunoprecipitated with NPC1 (Niemann–Pick disease type C1), an endocytic regulator of LDL trafficking. However, the cellular localization of LRP6 in the mutant cells shifted from cell surface to late endosomes/lysosomes. Plasma membrane expression levels of LRP6 R611C was lower compared to wild-type receptor and declined to a greater extent in LDL-rich medium. Further examinations revealed lower efficacy of apolipoprotein B dissociation from LRP6 R611C compared to wild-type receptor at an acidic pH. These studies identify LRP6 as a receptor for LDL endocytosis and imply that R611C mutation results in reduced LRP6 membrane expression and decreased LDL clearance. Based on our findings, we conclude that the increased affinity of the mutant receptor for LDL in acidic pH leads to their impaired dissociation in late endosomes, which compromises their recycling to the plasma membrane." @default.
• W2090277946 created "2016-06-24" @default.
• W2090277946 creator A5038979649 @default.
• W2090277946 creator A5041279122 @default.
• W2090277946 creator A5041366828 @default.
• W2090277946 creator A5053770757 @default.
• W2090277946 creator A5061851261 @default.
• W2090277946 creator A5078477564 @default.
• W2090277946 date "2008-11-21" @default.
• W2090277946 modified "2023-09-26" @default.
• W2090277946 title "Mutation in EGFP Domain of LDL Receptor-Related Protein 6 Impairs Cellular LDL Clearance" @default.
• W2090277946 cites W1497397052 @default.
• W2090277946 cites W1611720630 @default.
• W2090277946 cites W1635607892 @default.
• W2090277946 cites W1743302011 @default.
• W2090277946 cites W1970339183 @default.
• W2090277946 cites W1985929283 @default.
• W2090277946 cites W1994922837 @default.
• W2090277946 cites W2013460988 @default.
• W2090277946 cites W2032409947 @default.
• W2090277946 cites W2037132744 @default.
• W2090277946 cites W2039682492 @default.
• W2090277946 cites W2051907575 @default.
• W2090277946 cites W2052749020 @default.
• W2090277946 cites W2059813073 @default.
• W2090277946 cites W2075115500 @default.
• W2090277946 cites W2075460910 @default.
• W2090277946 cites W2076131647 @default.
• W2090277946 cites W2077576735 @default.
• W2090277946 cites W2087757733 @default.
• W2090277946 cites W2091242259 @default.
• W2090277946 cites W2091258025 @default.
• W2090277946 cites W2092905531 @default.
• W2090277946 cites W2097465600 @default.
• W2090277946 cites W2106281886 @default.
• W2090277946 cites W2108624125 @default.
• W2090277946 cites W2114511731 @default.
• W2090277946 cites W2126528483 @default.
• W2090277946 cites W2134893181 @default.
• W2090277946 cites W2138512695 @default.
• W2090277946 cites W2140997828 @default.
• W2090277946 cites W2143863227 @default.
• W2090277946 cites W2153350589 @default.
• W2090277946 cites W2163329733 @default.
• W2090277946 doi "https://doi.org/10.1161/circresaha.108.183863" @default.
• W2090277946 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3426315" @default.
• W2090277946 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18948618" @default.
• W2090277946 hasPublicationYear "2008" @default.
• W2090277946 type Work @default.
• W2090277946 sameAs 2090277946 @default.
• W2090277946 citedByCount "44" @default.
• W2090277946 countsByYear W20902779462012 @default.
• W2090277946 countsByYear W20902779462013 @default.
• W2090277946 countsByYear W20902779462014 @default.
• W2090277946 countsByYear W20902779462015 @default.
• W2090277946 countsByYear W20902779462016 @default.
• W2090277946 countsByYear W20902779462017 @default.
• W2090277946 countsByYear W20902779462018 @default.
• W2090277946 countsByYear W20902779462019 @default.
• W2090277946 countsByYear W20902779462020 @default.
• W2090277946 countsByYear W20902779462021 @default.
• W2090277946 countsByYear W20902779462022 @default.
• W2090277946 crossrefType "journal-article" @default.
• W2090277946 hasAuthorship W2090277946A5038979649 @default.
• W2090277946 hasAuthorship W2090277946A5041279122 @default.
• W2090277946 hasAuthorship W2090277946A5041366828 @default.
• W2090277946 hasAuthorship W2090277946A5053770757 @default.
• W2090277946 hasAuthorship W2090277946A5061851261 @default.
• W2090277946 hasAuthorship W2090277946A5078477564 @default.
• W2090277946 hasBestOaLocation W20902779461 @default.
• W2090277946 hasConcept C102747710 @default.
• W2090277946 hasConcept C104317684 @default.
• W2090277946 hasConcept C126322002 @default.
• W2090277946 hasConcept C134018914 @default.
• W2090277946 hasConcept C137620995 @default.
• W2090277946 hasConcept C139770010 @default.
• W2090277946 hasConcept C143065580 @default.
• W2090277946 hasConcept C153911025 @default.
• W2090277946 hasConcept C170320316 @default.
• W2090277946 hasConcept C170493617 @default.
• W2090277946 hasConcept C185350488 @default.
• W2090277946 hasConcept C185592680 @default.
• W2090277946 hasConcept C2778163477 @default.
• W2090277946 hasConcept C2780072125 @default.
• W2090277946 hasConcept C28005876 @default.
• W2090277946 hasConcept C43554185 @default.
• W2090277946 hasConcept C55493867 @default.
• W2090277946 hasConcept C62478195 @default.
• W2090277946 hasConcept C62746215 @default.
• W2090277946 hasConcept C71924100 @default.
• W2090277946 hasConcept C79747257 @default.
• W2090277946 hasConcept C86803240 @default.
• W2090277946 hasConcept C95444343 @default.
• W2090277946 hasConceptScore W2090277946C102747710 @default.
• W2090277946 hasConceptScore W2090277946C104317684 @default.
• W2090277946 hasConceptScore W2090277946C126322002 @default.
• W2090277946 hasConceptScore W2090277946C134018914 @default.
• W2090277946 hasConceptScore W2090277946C137620995 @default.

• next