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- W2090286855 abstract "Die Aktivität des metabolischen Schlüsselenzyms PriA aus Mycobacterium tuberculosis (mtPriA) kann reversibel durch Licht kontrolliert werden. Auf der Grundlage des Dithienylethen-Gerüsts wurden entsprechend der zweifachen Rotationssymmetrie des Proteins symmetrische Inhibitoren mit terminalen Ankern entworfen. Durch Schalten vom flexiblen, offenen Isomer zur starren, geschlossenen Form wurde die Inhibitionsaktivität um eine Größenordnung reduziert." @default.
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- W2090286855 date "2013-11-25" @default.
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- W2090286855 title "Nutzung natürlicher Proteinsymmetrie zum Design lichtschaltbarer Enzyminhibitoren" @default.
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