Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090294867> ?p ?o ?g. }
- W2090294867 endingPage "470" @default.
- W2090294867 startingPage "458" @default.
- W2090294867 abstract "Sel1L is an essential adaptor protein for the E3 ligase Hrd1 in the endoplasmic reticulum (ER)-associated degradation (ERAD), a universal quality-control system in the cell; but its physiological role remains unclear. Here we show that mice with adipocyte-specific Sel1L deficiency are resistant to diet-induced obesity and exhibit postprandial hypertriglyceridemia. Further analyses reveal that Sel1L is indispensable for the secretion of lipoprotein lipase (LPL), independent of its role in Hrd1-mediated ERAD and ER homeostasis. Sel1L physically interacts with and stabilizes the LPL maturation complex consisting of LPL and lipase maturation factor 1 (LMF1). In the absence of Sel1L, LPL is retained in the ER and forms protein aggregates, which are degraded primarily by autophagy. The Sel1L-mediated control of LPL secretion is also seen in other LPL-expressing cell types including cardiac myocytes and macrophages. Thus, our study reports a role of Sel1L in LPL secretion and systemic lipid metabolism." @default.
- W2090294867 created "2016-06-24" @default.
- W2090294867 creator A5004517310 @default.
- W2090294867 creator A5005044274 @default.
- W2090294867 creator A5005312959 @default.
- W2090294867 creator A5008302088 @default.
- W2090294867 creator A5017691756 @default.
- W2090294867 creator A5020147975 @default.
- W2090294867 creator A5028162489 @default.
- W2090294867 creator A5028342693 @default.
- W2090294867 creator A5028940530 @default.
- W2090294867 creator A5035142056 @default.
- W2090294867 creator A5036570307 @default.
- W2090294867 creator A5047023747 @default.
- W2090294867 creator A5052467732 @default.
- W2090294867 creator A5063521272 @default.
- W2090294867 creator A5067167505 @default.
- W2090294867 creator A5067928546 @default.
- W2090294867 creator A5069044528 @default.
- W2090294867 creator A5069354151 @default.
- W2090294867 date "2014-09-01" @default.
- W2090294867 modified "2023-10-10" @default.
- W2090294867 title "The ER-Associated Degradation Adaptor Protein Sel1L Regulates LPL Secretion and Lipid Metabolism" @default.
- W2090294867 cites W1567804396 @default.
- W2090294867 cites W1604930697 @default.
- W2090294867 cites W1964873147 @default.
- W2090294867 cites W1966174134 @default.
- W2090294867 cites W1966526764 @default.
- W2090294867 cites W1970909688 @default.
- W2090294867 cites W1971694897 @default.
- W2090294867 cites W1984171106 @default.
- W2090294867 cites W1996902174 @default.
- W2090294867 cites W2017152530 @default.
- W2090294867 cites W2023975386 @default.
- W2090294867 cites W2025226894 @default.
- W2090294867 cites W2027706325 @default.
- W2090294867 cites W2035349696 @default.
- W2090294867 cites W2046021087 @default.
- W2090294867 cites W2047979617 @default.
- W2090294867 cites W2048969348 @default.
- W2090294867 cites W2049135972 @default.
- W2090294867 cites W2066700296 @default.
- W2090294867 cites W2078018592 @default.
- W2090294867 cites W2078039611 @default.
- W2090294867 cites W2085774288 @default.
- W2090294867 cites W2089666854 @default.
- W2090294867 cites W2090556647 @default.
- W2090294867 cites W2094898345 @default.
- W2090294867 cites W2097893773 @default.
- W2090294867 cites W2108905404 @default.
- W2090294867 cites W2111415532 @default.
- W2090294867 cites W2115706326 @default.
- W2090294867 cites W2124475225 @default.
- W2090294867 cites W2126746388 @default.
- W2090294867 cites W2137353223 @default.
- W2090294867 cites W2137392137 @default.
- W2090294867 cites W2137667514 @default.
- W2090294867 cites W2147833903 @default.
- W2090294867 cites W2153458899 @default.
- W2090294867 cites W2159504081 @default.
- W2090294867 cites W2161910349 @default.
- W2090294867 cites W2162695817 @default.
- W2090294867 cites W2162789070 @default.
- W2090294867 cites W2165186407 @default.
- W2090294867 cites W2168511938 @default.
- W2090294867 cites W2169883398 @default.
- W2090294867 cites W2338206367 @default.
- W2090294867 cites W2441242823 @default.
- W2090294867 cites W4212788380 @default.
- W2090294867 doi "https://doi.org/10.1016/j.cmet.2014.06.015" @default.
- W2090294867 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4156539" @default.
- W2090294867 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25066055" @default.
- W2090294867 hasPublicationYear "2014" @default.
- W2090294867 type Work @default.
- W2090294867 sameAs 2090294867 @default.
- W2090294867 citedByCount "87" @default.
- W2090294867 countsByYear W20902948672015 @default.
- W2090294867 countsByYear W20902948672016 @default.
- W2090294867 countsByYear W20902948672017 @default.
- W2090294867 countsByYear W20902948672018 @default.
- W2090294867 countsByYear W20902948672019 @default.
- W2090294867 countsByYear W20902948672020 @default.
- W2090294867 countsByYear W20902948672021 @default.
- W2090294867 countsByYear W20902948672022 @default.
- W2090294867 countsByYear W20902948672023 @default.
- W2090294867 crossrefType "journal-article" @default.
- W2090294867 hasAuthorship W2090294867A5004517310 @default.
- W2090294867 hasAuthorship W2090294867A5005044274 @default.
- W2090294867 hasAuthorship W2090294867A5005312959 @default.
- W2090294867 hasAuthorship W2090294867A5008302088 @default.
- W2090294867 hasAuthorship W2090294867A5017691756 @default.
- W2090294867 hasAuthorship W2090294867A5020147975 @default.
- W2090294867 hasAuthorship W2090294867A5028162489 @default.
- W2090294867 hasAuthorship W2090294867A5028342693 @default.
- W2090294867 hasAuthorship W2090294867A5028940530 @default.
- W2090294867 hasAuthorship W2090294867A5035142056 @default.
- W2090294867 hasAuthorship W2090294867A5036570307 @default.
- W2090294867 hasAuthorship W2090294867A5047023747 @default.