Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090304126> ?p ?o ?g. }
- W2090304126 endingPage "601" @default.
- W2090304126 startingPage "591" @default.
- W2090304126 abstract "Clinical, epidemiological and therapeutic studies indicate that some human depression is associated with proinflammatory cytokines, chronic inflammatory disorders, and inflammation-inducing lifestyle factors. Moreover depression can be induced by administration of proinflammatory cytokines, including IL-2 or IFN-α. However, recent studies in specific pathogen-free (SPF) rodents suggest a different--and potentially contradictory--relationship between immune processes and mental health. These studies suggest that effector T cells specific for central nervous system (CNS) antigens can assist recovery from an array of environmental insults ranging from nerve injury to psychological stress, while in contrast, regulatory T cells (Treg) oppose such recovery. Indeed, some reported effects of this so-called protective autoimmunity seem of direct relevance to depressive disorders. These findings pose a dilemma for those intending to manipulate inflammatory pathways as a treatment for depression. Should we administer anti-inflammatory treatments, or should we induce self-reactive T cells? We re-examine the rodent findings and outline immunological peculiarities of SPF rodents, the abnormal properties of their regulatory T cells, and the impact of gut microbiota. We find that protective autoimmunity is likely to be relevant only to very clean SPF animals that lack normal levels of activated T cells, CNS T cell traffic and mature Treg. The data indicate that even in SPF models the effectors of beneficial effects are not the proinflammatory autoimmune cells themselves, but rather unidentified regulatory cells. This reinterpretation of findings relevant to protective autoimmunity suggests that ongoing, and planned, clinical trials of anti-inflammatory strategies to treat depressive disorders are justified." @default.
- W2090304126 created "2016-06-24" @default.
- W2090304126 creator A5020963967 @default.
- W2090304126 creator A5024726266 @default.
- W2090304126 creator A5025539451 @default.
- W2090304126 date "2011-05-01" @default.
- W2090304126 modified "2023-10-18" @default.
- W2090304126 title "Lymphocytes in neuroprotection, cognition and emotion: Is intolerance really the answer?" @default.
- W2090304126 cites W1481521731 @default.
- W2090304126 cites W1514064771 @default.
- W2090304126 cites W1547225066 @default.
- W2090304126 cites W1547955534 @default.
- W2090304126 cites W1586876258 @default.
- W2090304126 cites W1653792289 @default.
- W2090304126 cites W1872870079 @default.
- W2090304126 cites W1900649416 @default.
- W2090304126 cites W1958681235 @default.
- W2090304126 cites W1963870368 @default.
- W2090304126 cites W1966761389 @default.
- W2090304126 cites W1968578486 @default.
- W2090304126 cites W1969847335 @default.
- W2090304126 cites W1976604523 @default.
- W2090304126 cites W1976968085 @default.
- W2090304126 cites W1977060822 @default.
- W2090304126 cites W1981736075 @default.
- W2090304126 cites W1982301384 @default.
- W2090304126 cites W1984429004 @default.
- W2090304126 cites W1985438873 @default.
- W2090304126 cites W1987285006 @default.
- W2090304126 cites W1990626639 @default.
- W2090304126 cites W1992985178 @default.
- W2090304126 cites W1993763786 @default.
- W2090304126 cites W1993764727 @default.
- W2090304126 cites W1993895495 @default.
- W2090304126 cites W1996454121 @default.
- W2090304126 cites W1997132511 @default.
- W2090304126 cites W1998079511 @default.
- W2090304126 cites W1998520631 @default.
- W2090304126 cites W1999883073 @default.
- W2090304126 cites W2006282784 @default.
- W2090304126 cites W2009521351 @default.
- W2090304126 cites W2009813808 @default.
- W2090304126 cites W2011361505 @default.
- W2090304126 cites W2012860078 @default.
- W2090304126 cites W2014060223 @default.
- W2090304126 cites W2017605183 @default.
- W2090304126 cites W2018049815 @default.
- W2090304126 cites W2019640842 @default.
- W2090304126 cites W2021918390 @default.
- W2090304126 cites W2024152763 @default.
- W2090304126 cites W2024677782 @default.
- W2090304126 cites W2032091790 @default.
- W2090304126 cites W2032432537 @default.
- W2090304126 cites W2034082915 @default.
- W2090304126 cites W2034630933 @default.
- W2090304126 cites W2039420382 @default.
- W2090304126 cites W2040443012 @default.
- W2090304126 cites W2041257968 @default.
- W2090304126 cites W2043087509 @default.
- W2090304126 cites W2044729604 @default.
- W2090304126 cites W2047082587 @default.
- W2090304126 cites W2049625461 @default.
- W2090304126 cites W2052042076 @default.
- W2090304126 cites W2052840092 @default.
- W2090304126 cites W2056487354 @default.
- W2090304126 cites W2058010310 @default.
- W2090304126 cites W2058425124 @default.
- W2090304126 cites W2058864165 @default.
- W2090304126 cites W2063986567 @default.
- W2090304126 cites W2065186655 @default.
- W2090304126 cites W2067640086 @default.
- W2090304126 cites W2068646115 @default.
- W2090304126 cites W2071336988 @default.
- W2090304126 cites W2074257485 @default.
- W2090304126 cites W2075372904 @default.
- W2090304126 cites W2077672919 @default.
- W2090304126 cites W2078701378 @default.
- W2090304126 cites W2080088660 @default.
- W2090304126 cites W2081117923 @default.
- W2090304126 cites W2088719066 @default.
- W2090304126 cites W2096129454 @default.
- W2090304126 cites W2097533850 @default.
- W2090304126 cites W2097740790 @default.
- W2090304126 cites W2100057942 @default.
- W2090304126 cites W2100288924 @default.
- W2090304126 cites W2101409687 @default.
- W2090304126 cites W2102265675 @default.
- W2090304126 cites W2103583885 @default.
- W2090304126 cites W2105484520 @default.
- W2090304126 cites W2106181827 @default.
- W2090304126 cites W2107868056 @default.
- W2090304126 cites W2108398194 @default.
- W2090304126 cites W2109261715 @default.
- W2090304126 cites W2110729320 @default.
- W2090304126 cites W2111800376 @default.
- W2090304126 cites W2113485611 @default.
- W2090304126 cites W2113754168 @default.
- W2090304126 cites W2113822705 @default.