Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090340820> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2090340820 endingPage "119" @default.
- W2090340820 startingPage "109" @default.
- W2090340820 abstract "Previous studies on neoplastic and hyperplastic ovarian lesions using paraffin-embedded material have demonstrated immunolocalization of sex steroid biosynthetic enzymes (SSBEs): P-450 side chain cleavage (P-450 SCC), which converts cholesterol to pregnenolone; 3 beta-hydroxysteroid dehydrogenase (3 beta-HSD), which converts pregnenolone to progesterone; P-450 17 alpha-hydroxylase and lyase (P-450 17A), which convert progesterone to 17 alpha-hydroxyprogesterone and 4-androstene-3,17-dione; and P-450 aromatase (P-450 AR), which converts 4-androstene-3,17-dione to estradiol. To investigate the utility of immunohistochemical staining for SSBEs, we studied a series of 45 sex cord-stromal tumors of the ovary. P-450 SCC was present in 9 of 11 Sertoli-stromal cell tumors, 3 of 12 granulosa cell tumors, 2 of 7 thecomas, and 1 of 1 stromal luteomas; 3 beta-HSD was present in 5 of 11 Sertoli-stromal cell tumors, 2 of 12 granulosa cell tumors, 2 of 7 thecomas, and 1 of 1 stromal luteoma; P-450 17A was present in 5 of 11 Sertoli-stromal cell tumors, 2 of 12 granulosa cell tumors, 2 of 6 thecomas, and 1 of 1 stromal luteomas; P-450 AR was present in 6 of 11 Sertoli-stromal cell tumors, 2 of 12 granulosa cell tumors, none of 7 thecomas, and 1 of 1 stromal luteoma. SSBEs were not present in 12 fibromas, one sclerosing stromal tumor, and one myxoma. Five of 45 patients with sex cord-stromal tumors showed androgenic effects; 4 of 11 patients with Sertoli-stromal cell tumors and the patient with a stromal luteoma. These five sex cord-stromal tumors contained P-450 SCC, and three of four of the Sertoli-stromal cell tumors contained 3 beta-HSD, P-450 17A, and P-450 AR. Concurrent endometrial histology was available in 25 of 45 sex cord-stromal tumor patients. None of the five sex cord-stromal tumors arising in patients with endometria that showed hyperplasia or adenocarcinoma showed immunoreactivity for SSBEs. Eight patients' endometria were unremarkable, but their sex cord-stromal tumor contained SSBEs. SSBEs were present in areas showing Leydig cell, Sertoli cell, or steroid cell differentiation or luteinized areas; however, the results did not significantly add to the histologic classification of sex-cord stromal tumors. Androgenic hormonal effects could always be explained by synthesis of hormones by SSBEs present in the patient's sex cord-stromal tumor.(ABSTRACT TRUNCATED AT 400 WORDS)" @default.
- W2090340820 created "2016-06-24" @default.
- W2090340820 creator A5010511093 @default.
- W2090340820 creator A5015575554 @default.
- W2090340820 creator A5083088049 @default.
- W2090340820 date "1994-04-01" @default.
- W2090340820 modified "2023-10-18" @default.
- W2090340820 title "Sex Steroid Biosynthesis Enzymes in Ovarian Sex-Cord Stromal Tumors" @default.
- W2090340820 doi "https://doi.org/10.1097/00004347-199404000-00002" @default.
- W2090340820 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8005731" @default.
- W2090340820 hasPublicationYear "1994" @default.
- W2090340820 type Work @default.
- W2090340820 sameAs 2090340820 @default.
- W2090340820 citedByCount "16" @default.
- W2090340820 countsByYear W20903408202013 @default.
- W2090340820 countsByYear W20903408202014 @default.
- W2090340820 countsByYear W20903408202016 @default.
- W2090340820 crossrefType "journal-article" @default.
- W2090340820 hasAuthorship W2090340820A5010511093 @default.
- W2090340820 hasAuthorship W2090340820A5015575554 @default.
- W2090340820 hasAuthorship W2090340820A5083088049 @default.
- W2090340820 hasConcept C121608353 @default.
- W2090340820 hasConcept C123765429 @default.
- W2090340820 hasConcept C126322002 @default.
- W2090340820 hasConcept C134018914 @default.
- W2090340820 hasConcept C142724271 @default.
- W2090340820 hasConcept C16930146 @default.
- W2090340820 hasConcept C2776166826 @default.
- W2090340820 hasConcept C2777203538 @default.
- W2090340820 hasConcept C2777736315 @default.
- W2090340820 hasConcept C2778324911 @default.
- W2090340820 hasConcept C2778575703 @default.
- W2090340820 hasConcept C2780193516 @default.
- W2090340820 hasConcept C2780902042 @default.
- W2090340820 hasConcept C2781068068 @default.
- W2090340820 hasConcept C502942594 @default.
- W2090340820 hasConcept C530470458 @default.
- W2090340820 hasConcept C71315377 @default.
- W2090340820 hasConcept C71924100 @default.
- W2090340820 hasConcept C86803240 @default.
- W2090340820 hasConceptScore W2090340820C121608353 @default.
- W2090340820 hasConceptScore W2090340820C123765429 @default.
- W2090340820 hasConceptScore W2090340820C126322002 @default.
- W2090340820 hasConceptScore W2090340820C134018914 @default.
- W2090340820 hasConceptScore W2090340820C142724271 @default.
- W2090340820 hasConceptScore W2090340820C16930146 @default.
- W2090340820 hasConceptScore W2090340820C2776166826 @default.
- W2090340820 hasConceptScore W2090340820C2777203538 @default.
- W2090340820 hasConceptScore W2090340820C2777736315 @default.
- W2090340820 hasConceptScore W2090340820C2778324911 @default.
- W2090340820 hasConceptScore W2090340820C2778575703 @default.
- W2090340820 hasConceptScore W2090340820C2780193516 @default.
- W2090340820 hasConceptScore W2090340820C2780902042 @default.
- W2090340820 hasConceptScore W2090340820C2781068068 @default.
- W2090340820 hasConceptScore W2090340820C502942594 @default.
- W2090340820 hasConceptScore W2090340820C530470458 @default.
- W2090340820 hasConceptScore W2090340820C71315377 @default.
- W2090340820 hasConceptScore W2090340820C71924100 @default.
- W2090340820 hasConceptScore W2090340820C86803240 @default.
- W2090340820 hasIssue "2" @default.
- W2090340820 hasLocation W20903408201 @default.
- W2090340820 hasLocation W20903408202 @default.
- W2090340820 hasOpenAccess W2090340820 @default.
- W2090340820 hasPrimaryLocation W20903408201 @default.
- W2090340820 hasRelatedWork W1972664531 @default.
- W2090340820 hasRelatedWork W1979589658 @default.
- W2090340820 hasRelatedWork W2013076294 @default.
- W2090340820 hasRelatedWork W2023028417 @default.
- W2090340820 hasRelatedWork W2042670436 @default.
- W2090340820 hasRelatedWork W2071967854 @default.
- W2090340820 hasRelatedWork W2122696678 @default.
- W2090340820 hasRelatedWork W2148182143 @default.
- W2090340820 hasRelatedWork W2169825874 @default.
- W2090340820 hasRelatedWork W2400516310 @default.
- W2090340820 hasVolume "13" @default.
- W2090340820 isParatext "false" @default.
- W2090340820 isRetracted "false" @default.
- W2090340820 magId "2090340820" @default.
- W2090340820 workType "article" @default.