Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090341475> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2090341475 endingPage "354" @default.
- W2090341475 startingPage "345" @default.
- W2090341475 abstract "The direct effect of intravascularly injected vincristine on the rat brain was investigated after the osmotic opening of the blood-brain barrier. This was opened unilaterally by injecting 2.5 ml of 1.4 molal mannitol solution into the right carotid artery through a cannula inserted in the external carotid artery in retrograde fashion. Vincristine (0.75 mg/kg) was then injected into either the carotid artery or into a vein. Animals, thus treated, developed left hemiparesis and choreo-athetoid head motion within several days. Microscopical analysis revealed 1 intracytoplasmic eosinophilic inclusions at an early period, 2 neuronal argyrophilic change and axonal thickening with spheroid formation at later times, and 3 glial mitotic arrest, a finding not reported in the previous studies with intrathecal injection of vincristine. Neuronal changes were usually confined to the selected area in the midbrain, whereas glial mitotic figures were seen in the hippocampus, midbrain and cerebellum. These changes are thought to be direct effects of the vincristine binding with cellular microtubules, including mitotic spindle tubules and neurotubules. The transient opening of the blood-brain barrier seems to be a useful technique for studying the experimental neurotoxicology of drugs to which the blood-brain barrier is impermeable." @default.
- W2090341475 created "2016-06-24" @default.
- W2090341475 creator A5012252652 @default.
- W2090341475 creator A5071204961 @default.
- W2090341475 creator A5085556764 @default.
- W2090341475 date "1983-09-01" @default.
- W2090341475 modified "2023-09-27" @default.
- W2090341475 title "NEUROTOXICITY OF VINCRISTINE AFTER THE OSMOTIC OPENING OF THE BLOOD-BRAIN BARRIER" @default.
- W2090341475 cites W1246680299 @default.
- W2090341475 cites W1967547513 @default.
- W2090341475 cites W1996331958 @default.
- W2090341475 cites W2052204387 @default.
- W2090341475 cites W2086963537 @default.
- W2090341475 cites W2096475248 @default.
- W2090341475 cites W2100863198 @default.
- W2090341475 cites W2146439525 @default.
- W2090341475 cites W2300592427 @default.
- W2090341475 cites W4233026774 @default.
- W2090341475 cites W4235195095 @default.
- W2090341475 doi "https://doi.org/10.1111/j.1365-2990.1983.tb00120.x" @default.
- W2090341475 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6316187" @default.
- W2090341475 hasPublicationYear "1983" @default.
- W2090341475 type Work @default.
- W2090341475 sameAs 2090341475 @default.
- W2090341475 citedByCount "44" @default.
- W2090341475 countsByYear W20903414752012 @default.
- W2090341475 countsByYear W20903414752016 @default.
- W2090341475 countsByYear W20903414752019 @default.
- W2090341475 countsByYear W20903414752021 @default.
- W2090341475 crossrefType "journal-article" @default.
- W2090341475 hasAuthorship W2090341475A5012252652 @default.
- W2090341475 hasAuthorship W2090341475A5071204961 @default.
- W2090341475 hasAuthorship W2090341475A5085556764 @default.
- W2090341475 hasConcept C105702510 @default.
- W2090341475 hasConcept C126322002 @default.
- W2090341475 hasConcept C142724271 @default.
- W2090341475 hasConcept C185592680 @default.
- W2090341475 hasConcept C2776694085 @default.
- W2090341475 hasConcept C2776755627 @default.
- W2090341475 hasConcept C2778402981 @default.
- W2090341475 hasConcept C2779429289 @default.
- W2090341475 hasConcept C42219234 @default.
- W2090341475 hasConcept C529278444 @default.
- W2090341475 hasConcept C71924100 @default.
- W2090341475 hasConcept C86803240 @default.
- W2090341475 hasConceptScore W2090341475C105702510 @default.
- W2090341475 hasConceptScore W2090341475C126322002 @default.
- W2090341475 hasConceptScore W2090341475C142724271 @default.
- W2090341475 hasConceptScore W2090341475C185592680 @default.
- W2090341475 hasConceptScore W2090341475C2776694085 @default.
- W2090341475 hasConceptScore W2090341475C2776755627 @default.
- W2090341475 hasConceptScore W2090341475C2778402981 @default.
- W2090341475 hasConceptScore W2090341475C2779429289 @default.
- W2090341475 hasConceptScore W2090341475C42219234 @default.
- W2090341475 hasConceptScore W2090341475C529278444 @default.
- W2090341475 hasConceptScore W2090341475C71924100 @default.
- W2090341475 hasConceptScore W2090341475C86803240 @default.
- W2090341475 hasIssue "5" @default.
- W2090341475 hasLocation W20903414751 @default.
- W2090341475 hasLocation W20903414752 @default.
- W2090341475 hasOpenAccess W2090341475 @default.
- W2090341475 hasPrimaryLocation W20903414751 @default.
- W2090341475 hasRelatedWork W1936737016 @default.
- W2090341475 hasRelatedWork W1994089045 @default.
- W2090341475 hasRelatedWork W2027176817 @default.
- W2090341475 hasRelatedWork W2051938899 @default.
- W2090341475 hasRelatedWork W2142889357 @default.
- W2090341475 hasRelatedWork W2304342447 @default.
- W2090341475 hasRelatedWork W2406698057 @default.
- W2090341475 hasRelatedWork W2748952813 @default.
- W2090341475 hasRelatedWork W2899084033 @default.
- W2090341475 hasRelatedWork W965024924 @default.
- W2090341475 hasVolume "9" @default.
- W2090341475 isParatext "false" @default.
- W2090341475 isRetracted "false" @default.
- W2090341475 magId "2090341475" @default.
- W2090341475 workType "article" @default.