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- W2090349061 abstract "The effect of nicardipine on insulin secretion was examined in two double-blind, randomised, cross-over, placebo-controlled studies in normal volunteers. In the first study, the effect of acute dosing (via an intravenous infusion of 5 mg h-1 for 3 h) on the glucose, insulin, hormonal, and intermediary metabolite responses to an intravenous glucose tolerance test was determined in six healthy male volunteers. In the second study, the glucose, insulin, and C-peptide responses to intravenous tolbutamide (200 mg) was determined in another six male volunteers after oral dosing with nicardipine 30 mg three times daily for 1 week. A relative increase in insulin secretion was the principal finding of the first study. No other response was affected significantly. No significant differences between the nicardipine- and placebo-treated groups were noted in the insulin, glucose, and C- peptide measurements of the second study. In conclusion, treatment with nicardipine does not appear to impair insulin secretion in response either to an intravenous glucose load or intravenously administered tolbutamide." @default.
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- W2090349061 date "1985-02-01" @default.
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- W2090349061 title "The effect of nicardipine on glucose and drug-stimulated insulin secretion in normal volunteers." @default.
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- W2090349061 doi "https://doi.org/10.1111/j.1365-2125.1985.tb05146.x" @default.
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