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• W2090369715 abstract "Hyphantria cunea nucleopolyhedrovirus (HycuNPV) infection protected SpIm cells from actinomycin D (ActD)-induced apoptosis as early as 4 h postinfection. Analysis by Southern hybridization revealed that the HycuNPV genome possessed three members of inhibitor of apoptosis genes (iaps) that were designated as hycu-iap1, hycu-iap2, and hycu-iap3 because of their amino acid sequence homology with iaps identified in other baculoviruses. Functional analysis of Hycu-IAPs by transient expression assay in Sf9 cells revealed that Hycu-IAP3 blocked apoptosis induced by actinomycin D and rescued replication of p35 deficient-mutant AcMNPV, while Hycu-IAP1 and Hycu-IAP2 did not show any anti-apoptotic functions. Knockdown of hycu-iap3 expression by RNAi during HycuNPV infection in SpIm cells induced apoptosis. These results indicate that Hycu-IAP3 is essential for blockage of apoptosis during HycuNPV infection of permissive SpIm cells." @default.
• W2090369715 created "2016-06-24" @default.
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• W2090369715 date "2004-04-01" @default.
• W2090369715 modified "2023-09-28" @default.
• W2090369715 title "Identification and functional analysis of Hyphantria cunea nucleopolyhedrovirus iap genes" @default.
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• W2090369715 doi "https://doi.org/10.1016/j.virol.2004.01.002" @default.
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